Journal of Diseases

Published by: Asian Medical Journals
Online ISSN: 2410-6550
Print ISSN: 2413-838X
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No. 1

Nano Formulations of Natural Compounds for Enhanced Delivery

Pages: 14-20
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Nano Formulations of Natural Compounds for Enhanced Delivery

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DOI: 10.18488/journal.99.2017.41.14.20

Zahangir Alam

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Zahangir Alam (2017). Nano Formulations of Natural Compounds for Enhanced Delivery. Journal of Diseases, 4(1): 14-20. DOI: 10.18488/journal.99.2017.41.14.20
Natural products were always the key elements in ancient history that are promising to treat various diseases including cancer and prevent any health disorders. They have seen a breakthrough since they were used in cancer chemotherapy and prevention with selective phytochemicals. Fruits and vegetables contain nutrient constituents that are bioactive in disease states. Extensive in vitro and in vivo research data is available to prove their efficacy. While few compounds have successfully transitioned to the clinical trials, few of them are still facing problems due to their poor bioavailability and lack of targeting. The lack of efficacy in human studies can be attributed to the complexity of the biological system and complexity of food. In recent years, identification of molecular targets made it necessary to develop efficient formulations for delivery. Nano formulations such emulsions, nanoparticles and nano vesicles are few of the advancements that showed promising faith in natural product chemotherapy. This paper reviews few of the techniques employed for natural compound delivery which can be applied to various compounds.

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Multifactorial Analysis of the Parameters for Immunity in Preterm Infants

Pages: 8-13
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Multifactorial Analysis of the Parameters for Immunity in Preterm Infants

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DOI: 10.18488/journal.99/2017.4.1/99.1.8.13

N.L. Aryayev , I.M. Shevchenko , H.M. El Mezewghi , N.V. Shevchenko

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N.L. Aryayev , I.M. Shevchenko , H.M. El Mezewghi , N.V. Shevchenko (2017). Multifactorial Analysis of the Parameters for Immunity in Preterm Infants. Journal of Diseases, 4(1): 8-13. DOI: 10.18488/journal.99/2017.4.1/99.1.8.13
The multifactorial analysis of the immunity for the preterm infants, born at 34-36 weeks gestation, has been performed. Three factors of the external load, which were 55.71% of the power load, have been determined with the method of principal components. As a result of the analysis, we can come to the conclusion about the feasibility of the advanced study, the parameters of the immune system for the preterm infants, are as follows: The complement fractions, The circulating immune complexes, T-lymphocytes, T-helper cells, B-lymphocytes, the immunoregulatory index, and IgE.
Contribution/ Originality
This study is one of very few studies which have investigated parameter of immunity for preterm infants, study of the relationship of balance disorders and immune mechanisms in preterm infants will identify new approaches to the diagnosis of the pathology for neonatal period

Development of Periodontitis after Antihelicobacter Therapy in Patients with Ulcer Disease

Pages: 1-7
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Development of Periodontitis after Antihelicobacter Therapy in Patients with Ulcer Disease

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DOI: 10.18488/journal.99/2017.4.1/99.1.1.7

Shokhsanam Khurramova , Bekhzod Abdullaev

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Shokhsanam Khurramova , Bekhzod Abdullaev (2017). Development of Periodontitis after Antihelicobacter Therapy in Patients with Ulcer Disease. Journal of Diseases, 4(1): 1-7. DOI: 10.18488/journal.99/2017.4.1/99.1.1.7
Helicobacter pylori infection is associated with the most common diseases of the stomach and duodenum such as peptic ulcer, gastric cancer, and chronic gastritis. Stomach and duodenum are well-conditioned organs for bacteria. Oral cavity is considered a secondary reservoir of H. pylori. The infection responds well to complex antibacterial treatment, but the risk of recurrence and side effects of this treatment is sufficiently high. This article discusses the H.pylori-related pathology of oral cavity and paradentium, and the side effects and tolerability of eradication therapy. The pathways for optimization of the treatment for H. pylori infection with the use of drugs contributing to the restoration of microflora of the gastrointestinal tract and oral cavity are offered.
Contribution/ Originality
All authors contributed equally to this work. This study was one of few studies, which have investigated affecting antimicrobial and anti-ulcerative drugs to the development of periodontitis. Authors declare that there is found relations between pathogenesis of periodontitis and treatment of peptic ulcer disease.