Depression is a mental disorder, which could occur everyone. This also occurs in the seventh grade students who are approximately ages 12-13 years because they are facing the major changes, including physical, emotional development and social-cultural changes such as school and friends. It is also the time of the transition from elementary school to junior high school. This descriptive cross-sectional research aimed to investigate the relationships between gender, self-esteem, social support, and depression among the seventh grade students in junior high schools. The samples were 335 seventh grade students of junior high schools who lived in the Tanjungpinang, Indonesia. Data were collected using questionnaires and analyzed by Point-Biserial correlation coefficient, and Pearson Product-Moment Correlation Coefficient. The results showed that there were statistically significant relationships between gender, self-esteem, social support, and depression (r=.128, p<0.01; r= -.268, p < 0.05; r = -.147, p < 0.01). These findings indicated that gender, self-esteem and social support should be considered in preventing depression among seventh grade students in Junior High Schools.
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