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Journal of Diseases

March 2018, Volume 5, 1, pp 10-23

Genetic Insights of Cholesterol and Atherosclerosis; Complex Biology

Kishan L. Jadhav

,

Priyanka R. Kapare

,

Divya V. Khairmode

,

Chaitali H. Keskar

,

Akash S. Mali

Kishan L. Jadhav 1 ,

Priyanka R. Kapare 1 Divya V. Khairmode 1 Chaitali H. Keskar 1 Akash S. Mali 5

  1. Gourishankar Institute of Pharmaceutical Education and Research limb, Satara [MS] India 1

  2. Gourishankar Institute of Pharmaceutical Education and Research limb, Satara [MS] India.;Vytautas Magnus University, Kaunas, Lithuania 5

Pages: 10-23

DOI: 10.18488/journal.99.2018.51.6.19

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Article History:

Received: 25 June, 2018
Revised: 28 August, 2018
Accepted: 03 September, 2018
Published: 05 September, 2018


Abstract:

Atherosclerosis is multifaceted arterial disease involving collaboration of chromosomal and conservational factors; around seven million Americans are experiencing a heart attack during their lifetime. Many biomolecules play different roles in atherosclerosis such as 5-LO enzyme which play vital role in synthesis of leukotriene’s inflammatory intermediates and proteins. Previous studies show that individuals suffering from coronary artery disease more commonly have C. pneumonia antibody than inhabitant’s controls. In recent years the genes and genetic polymorphism which are associated with atherosclerosis had been identified. Phospholipid transfer protein will subsequently decrease the HDL mass and cholesterol efflux capacity due to its overexpression and deletation. Our aim of this review is to demonstrate complex biology of atherosclerosis and effect of cholesterol in cardiovascular diseases.
Contribution/ Originality
This study is one of very few studies which have investigated for genetical treatment of atherosclerosis. This study uses new estimation methodology such as by inhibiting RCT. This contributes information about molecular genetic changes in atherosclerosis which open up new vista for further research work.

Keywords:

Atherosclerosis, Cholesterol, Apo-E gene, QTL, Reverse cholesterol transport Cardiovascular diseases, C.pneumoniae

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Funding:

The authors are thankful to Riddhi Kamble and Principle, Gourishankar institute of pharmaceutical education and research limb, Satara [MS] India

Competing Interests:

The authors declare that they have no competing interests.

Acknowledgement:

All authors are equally contributed.

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