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Journal of Diseases

February 2017, Volume 4, 2, pp 27-33

Prevalence of Prediabetes and the Associated Risk of Kidney Disease in Apparently Healthy Subjects in Nnewi, Anambra State, Nigeria

Ozomma O.P, Ogbodo E.C, Analike R.A, Ezeugwunne I.P, Onah C.E, Amah U.K, Ugwu M.C, Obiorah M.O, Oha P.C, Egbe J.U, Meludu S.C

Ozomma O.P 1 Egbe J.U 1 

Meludu S.C 3 Ogbodo E.C 1 ,
;

Analike R.A 5 Ezeugwunne I.P 3 Onah C.E 7
Amah U.K 5 Ugwu M.C 1 Obiorah M.O 1 Oha P.C 1 

  1. Department of Medical Laboratory Science, Faculty of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria 1

  2. Department of Medical Laboratory Science, Faculty of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus; Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria 3

  3. Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria 5

  4. Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria 7

Pages: 27-33

DOI: 10.18488/journal.99.2017.42.27.33

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Article History:

Received: 24 May, 2017
Revised: 15 August, 2017
Accepted: 21 August, 2017
Published: 28 August, 2017


Abstract:

This study was designed to investigate the prevalence of prediabetes and the associated risk of kidney disease in Nnewi, Nigeria. A total of 277 apparently healthy subjects (73males and 204 females) who were willing to participate were recruited. Anthropometric indices and blood pressure were measured using standard methods while the demographic data and dietary pattern of subjects were obtained using a well-structured questionnaire.  5mls of blood was collected from eligible subjects (20 prediabetes and 20 non prediabetes ) and dispensed in fluoride oxalate and plain containers for glucose, creatinine (Cr), Urea(Ur), Na+, K+, Cl-, and HCO3- estimation respectively using standard methods. The result showed a prevalence of 7.2% prediabetes in the population. BMI was significantly higher in prediabetes than the control groups (39.4±5.8 vs 29±4.4kg/m2; P>0.05). Again, significant increases in the prediabetic values of FBG (117.54±16.84 vs 83±16.84mg/dl; P>0.05) than the control group were observed. The SBP (128± 11.26 vs 120±2.2mmHg; P>0.05) and DBP (92±4.43 vs 60±5.3mmHg; P>0.05) was also higher in prediabetic groups. Interestingly, result showed  no significant difference between the renal parameters in prediabetes and non prediabetes (p>0.05). The study therefore, suggests that the major determinant for predabetes in the study population may be hypertension and obesity whereas kidney function was not impaired.

Contribution/ Originality
This study documents the Prevalence of Prediabetes and the associated risk of kidney disease in apparently healthy individuals in Nnewi, Anambra State, Nigeria.

Keywords:

Prediabetes, Fasting blood glucose, Creatinine, Urea, Sodium, Potassium, Chloride, Bicarbonate, Diastolic blood pressure, Systolic blood pressure

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Funding:

This study received no specific financial support.

Competing Interests:

The author declares that there are no conflicts of interests regarding the publication of this paper.

Acknowledgement:

I am highly indebted to God Almighty who has been my constant source of inspiration and strength. In him I live, move and have my being and his grace is really sufficient for me. I wonder what the journey would have been like without his abiding love. To my Wonderful Supervisors Prof S.C. Meludu for his unflinching support, love and care whom his supervision went beyond official work of a supervisor you have been a great pillar to my academic success and, I give a million thanks sir, and Mrs R.A   Analike, Words cannot be sufficient to express my sincere gratitude towards your   inestimable  advice and support, you are really a mother. “Thank you” very much for your great help.I must not fail to also acknowledge my lecturers: Dr Ukaibe, Mrs Analike,  Mrs Ochiabuto  Mr. Sam, Mr  Okeke, Mrs Onwasanya,  Dr chukwuma, Dr Odiegwu ,Mr Ihim , Mr Jackson and all the scientist in chemical pathology department NAUTH  for  there immence contribution towards the success of  these  research work  and many others.  You all have really done an excellent job on me. You nurtured me from  naivety to sophistication. Thank you very much and may the good Lord continue to shower His blessing on you.I also will not forget to give my humble thanks to my dearest parents; Chief  and  Mrs  J.I, Ozomma and my siblings for their inestimable support and encouragement right from the day my sojourn on earth begun also my special appreciation goes to my big uncle Mr Ikejiofor, will not fail to appreciate your financial support towards the success of this work . My dearest and most trusted friend, Emmanuel Agbata, I cannot forget you  in a hurry, you have really been a great and positive influence on me. Your support, advice and encouragement has really seen me through, may God turn all your hopes, dreams and aspiration into reality. Also all who contributed in one way or the other especially Bernice, Evans, chisom  ,Imelda, Maryrose, Emma and all my classmates , i say a very big thanks to you all.
From the very depths of my heart I say thank you very much and may God bless you all.  

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