Background: There is a great confusion in the scientific literature
regarding tumors composed of tissues with different histogenetic and
molecular characteristics. Diagnosis of a neoplasm composed of more than
one tumoral tissue can be extremely challenging, so is the treatment.
Methods: This is an attempt, illustrated with several examples of these
types of tumors from the gnathic system, to gain a better understanding
of this issue. Conclusions: As the best of our knowledge, this is the
first report of a collision tumor between a sarcomatoid carcinoma and so
called keratocystic odontogenic tumor. It is critical to understand
these types of tumors, for correct diagnosis, staging and treatment.
This paper contributes to the understanding of complex tumors that are
usually difficult to diagnose and treat. A tumor with more than one
histogenetic characteristic constitutes a challenge for the medical
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This study received no specific financial support.
The authors declare that they have no competing interests.
All authors contributed equally to the conception and design of the study.