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Journal of Diseases

February 2016, Volume 3, 2, pp 21-29

Tumors of the Gnathic System with Multiple Histogenetic Characteristics

Friedman, Kurt


Luis Tamara


Ines Velez

Friedman, Kurt 1
Luis Tamara 2
Ines Velez 3

  1. Oral and Maxillofacial Surgeon, American Board of Oral and Maxillofacial Surgery, 1 SW 129th Ave #400, Pembroke Pines, FL 33027 1

  2. Americam Boards of Internal Medicine, Nuclear Medicine, Nuclear Cardiology, Nuclear Technology, Chief of Nuclear Medicine and PET/CT. VAMC. Houston Texas 2

  3. American Board of Oral and Maxillofacial Pathology, Professor and Director, Oral and Maxillofacial Pathology, Nova Southeastern University, 3200 S University Dr, Fort Lauderdale, Fl 33328 3

Pages: 21-29

DOI: 10.18488/journal.99/2016.3.2/

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Article History:

Received: 03 October, 2016
Revised: 22 October, 2016
Accepted: 03 November, 2016
Published: 08 November, 2016


Background: There is a great confusion in the scientific literature regarding tumors composed of tissues with different histogenetic and molecular characteristics. Diagnosis of a neoplasm composed of more than one tumoral tissue can be extremely challenging, so is the treatment.  Methods: This is an attempt, illustrated with several examples of these types of tumors from the gnathic system, to gain a better understanding of this issue. Conclusions: As the best of our knowledge, this is the first report of a collision tumor between a sarcomatoid carcinoma and so called keratocystic odontogenic tumor. It is critical to understand these types of tumors, for correct diagnosis, staging and treatment.
Contribution/ Originality
This paper contributes to the understanding of complex tumors that are usually difficult to diagnose and treat. A tumor with more than one histogenetic characteristic constitutes a challenge for the medical profession. 


Tumors, Orofacial, Histogenetic, Collision, Combined tumors



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This study received no specific financial support.

Competing Interests:

The authors declare that they have no competing interests.


All authors contributed equally to the conception and design of the study.

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