Taurodontism is a clinical condition found in the molar teeth of humans whereby the body of the tooth and pulp chamber is enlarged vertically at the expense of the roots. As a result, the floor of the pulp and the furcation of the tooth is moved apically down the root. It is due to the failure or late invagination of Hertwig’s epithelial root sheath, which is responsible for root formation and shaping causing an apical shift of the root furcation. The constriction at the amelocemental junction is abnormally formed. Taurodontism is most commonly found in permanent dentition although the term is traditionally applied to molar teeth. It has been reported that taurodontism follows an autosomal dominant type of inheritance. Meanwhile, Mutations or chromosome aberrations are considered alterations in the chromosome number or structure. They are mainly considered due to gametogenesis inborn error at meiosis, where DNA loses are seen due to DNA repair processes deficiency. Some chromosome studies were performed were 34.6% (1596 patients) showed different chromosome alterations. Among the studies population, male and female pediatric patients with sexual genetic diseases were chosen. These chromosome changes are classified as numeric or structural alterations, respectively. A wide variety of pediatric patients with genetic diseases chromosome alterations are described in this study analyzing their clinical characteristics, medical, surgical treatments and their clinical evolution according to the genetic disease.
This study contributes in the existing literature the relation of a well known genetic syndrome as klinefelter, a sexual chromosome alteration (47, XXY) and pediatric patients with taurodontism, an oral situation with teeth roots that grow crookedly with very huge teeth, likened to a bull.
J. C. Shaw, "Taurodont teeth in South African races," J. Anat., vol. 62, pp. 476-499, 1928.
A. Kahn Michael, "Basic oral and maxillofacial pathology," Oral & Maxillofacial Pathology, vol. 1, pp. 3-25, 2001.
M. Thanbichler, S. C. Wang, and L. Shapiro, "The bacterial nucleoid: A highly organized and dynamic structure," J. Cell Biochem., vol. 96, pp. 506–521, 2005.
K. Sandman and J. N. Reeve, "Structure and functional relationships of archaeal and eukaryal histones and nucleosomes," Arch. Microbiol., vol. 173, pp. 165–169, 2000.
S. L. Pereira, R. A. Grayling, R. Lurz, and J. N. Reeve, "Archaeal nucleosomes," Proc. Natl. Acad. Sci. U.S.A, vol. 94, pp. 12633–12637, 1997.
E. Paux, P. Sourdille, and J. Salse, "A physical map of the 1gigabase bread wheat chromosome 3B," Science, vol. 322, pp. 101–104, 2008.
M. J. D. White, The chromosomes. London, New York: Chapman and Hall, Distributed by Halsted Press, 1973.
M. Thanbichler and L. Shapiro, "Chromosome organization and segregation in bacteria," J. Struct. Biol., vol. 156, pp. 292–303, 2006.
A. Nakabachi, A. Yamashita, H. Toh, H. Ishikawa, H. Dunbar, N. Moran, and M. Hattori, "The 160kilobase genome of the bacterial endosymbiont carsonella," Science, vol. 314, pp. 267-275, 2006.
S. Pradella, A. Hans, C. Spröer, H. Reichenbach, K. Gerth, and S. Beyer, "Characterisation, genome size and genetic manipulation of the myxobacterium sorangium cellulosum So ce56," Arch. Microbiol., vol. 178, pp. 484–492, 2002.
H. Von Winiwarter, "Études sur la spermatogenese humaine," Arch. Biologie., vol. 27, pp. 147–149, 1912.
T. S. Painter, "Studies in mammalian spermatogenesis II. The spermatogenesis of man," J. Exp. Zoology, vol. 37, pp. 291–336, 1923.
J. H. Tjio and A. Levan, "The chromosome number of man," Hereditas, vol. 42, pp. 1–6, 1956.
J. Hinnebusch and K. Tilly, "Linear plasmids and chromosomes in bacteria," Mol. Microbiol., vol. 10, pp. 917–922, 1993.
J. M. Opitz, J. L. Frias, J. E. Gutenberger, and J. R. Pellett, "The G síndrome of multiple congenital anomalies," Birth Defects Orig. Art Ser., vol. 2, pp. 95-101, 1969.
R. J. M. Aparicio, L. F. Cuellar, H. Hurtado, P. M. Barrientos, D. M. S. Reynoso, G. R. Vargas, G. S. F. Camacho, G. I. Marroquin, M. S. Chatelain, and P. F. Sierra, "Disorders of sexual development in genetic pediatrics. Three different ambiguous genitalia cases report from hospital para El Nino Poblano, México," International Journal of Genetics and Molecular Biology, vol. 2, pp. 182-189, 2010.
L. G. Wilming, J. G. R. Gilbert, K. Howe, S. Trevanion, T. Hubbard, and J. L. Harrow Vega Sanger.ad.u, "Vertebrate genome annotation (VEGA) database," Nucleic Acid Research, vol. 36, pp. 753-760, 2008.
T. C. Hsu, Human and mammalian cytogenetics: A historical perspective. N.Y: Springer Verlag, 1979.
J. L. Huret, C. Leonard, and J. R. K. Savage, "Cromosomas, anomalias cromosómicas," Atlas Genet Cytogenet Oncol. Haematol, vol. 2, pp. 206-226, 2000.
J. L. Huret, C. Leonard, and J. R. K. Savage, "Crom, anomalias cromosómicas," Atlas Genet Cytogenet Oncol. Haematol, vol. 1, pp. 3-17, 2000.
L. M. Kelman and Z. Kelman, "Multiple origins of replication in archaea," Trends Microbiol., vol. 12, pp. 399–401, 2004.