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Journal of Diagnostics

June 2015, Volume 2, 2, pp 10-17

Reliability of the Laboratory Risk Indicator for Necrotizing Fasciitis (Lrinec) Score for Early Diagnosis of Necrotizing Fasciitis

Martis Manohar H. M., Prathvi Shetty, Hegde B. R.

Martis Manohar H. M. 1 ,

Prathvi Shetty 1 Hegde B. R. 1 
  1. Department of General Surgery, Fr. Muller Medical College Hospital, Kankanady, Mangalore, Karnataka, India 1

Pages: 10-17

DOI: 10.18488/journal.98/2015.2.2/

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Objective: Necrotizing fasciitis is a surgical emergency often requiring prompt diagnosis and treatment. Delay in surgical intervention can have catastrophic results including death. The laboratory risk indicator for necrotizing fasciitis (LRINEC) score uses laboratory parameters to assess the severity of infection and helps in early recognition of necrotizing fasciitis.  In this study, we collected the data of 40 patients diagnosed and treated as necrotizing fasciitis to validate the reliability of this score in early diagnosis of necrotizing fasciitis. Materials and methods: This is a retrospective study. Data of 40 patients admitted to Fr. Muller Medical College Hospital, Mangalore from August, 2012 to August, 2014 with a clinical diagnosis of Necrotizing fasciitis was analyzed and relevant statistical tests were applied to evaluate the reliability of the LRINEC score. Results: A total of 40 patients were included in the study. A LRINEC score of > 6 had a sensitivity of   93.10 %, specificity of 90.91%, positive predictive value of 96.43%, and negative predictive value of 83.33%. The most common organism isolated on culture was Staphylococcus aureus. Conclusion: The LRINEC score is an impressive diagnostic tool to differentiate between necrotizing fasciitis and other less severe soft tissue infections. It aids in early recognition of necrotizing fasciitis enabling prompt and appropriate treatment.
Contribution/ Originality
This study contributes to the existing literature on the reliability of the LRINEC score in early diagnosis of necrotizing fasciitis. It establishes the conclusion of previous studies that a universally reproducible scoring system like the LRINEC score is essential for the early and accurate management of necrotizing fasciitis. 




  1. G. Kihiczak, R. Schwartz, and R. Kapila, "Necrotizing fasciitis: A deadly infection," J. Eur. Acad. Dermatol Venereol, vol. 20, p. 365—369, 2006.
  2. R. Salcido, "Necrotizing fasciitis: Reviewing the causes and treatment strategies," Adv. Skin Wound Care, vol. 20, pp. 288— 293. Quiz 94-5, 2007.
  3. S. Tang, T. Kwok, and P. Ho, "Necrotizing fasciitis in a renal transplant recipient treated with FK 506: The first reported case," Clin. Nephrol., vol. 56, p. 481—485, 2001.
  4. W. Tang, P. Ho, and K. Fung, "Necrotising fasciitis of a limb," J. Bone Joint Surg. Br., vol. 83, p. 709—714, 2001.
  5. J. Trent and R. Kirsner, "Diagnosing necrotizing fasciitis," Adv. Skin Wound Care, vol. 15, p. 135—138, 2002.
  6. M. Cainzos and F. Gonzalez-Rodriguez, "Necrotizing soft tissue infections," Curr. Opin. Crit. Care, vol. 13, p. 433—439, 2007.
  7. C. McHenry, J. Piotrowski, D. Petrinic, and M. Malangoni, "Deter- minants of mortality for necrotizing soft-tissue infections," Ann. Surg., vol. 221, pp. 558–563. Discussion 563–565, 1995.
  8. G. Singh, S. Sinha, S. Adhikary, K. Babu, P. Ray, and S. Khanna, "Necrotising infections of soft tissues–a clinical profile," Eur. J. Surg., vol. 168, pp. 366–371, 2002.
  9. D. Elliott, J. Kufera, and R. Myers, "Necrotizing soft tissue infec- tions. Risk factors for mortality and strategies for management," Ann. Surg., vol. 224, pp. 672–683, 1996.
  10. C. Wong, H. Chang, S. Pasupathy, L. Khin, J. Tan, and C. Low, "Necrotizing fasciitis: Clinical presentation, microbiology, and determinants of mortality," J. Bone Joint Surg. Am., vol. 85-A, pp. 1454–1460, 2003.
  11. D. Voros, C. Pissiotis, D. Georgantas, S. Katsaragakis, S. Antoniou, and J. Papadimitriou, "Role of early and extensive surgery in the treat- ment of severe necrotizing soft tissue infection," Br. J. Surg., vol. 80, pp. 1190–1191, 1993.
  12. J. Majeski and J. Alexander, "Early diagnosis, nutritional support, and immediate extensive debridement improve survival in nec- rotizing fasciitis," Am. J. Surg., vol. 145, pp. 784–787, 1983.
  13. B. Bilton, G. Zibari, R. McMillan, D. Aultman, G. Dunn, and J. McDonald, "Aggressive surgical management of necrotizing fasciitis serves to decrease mortality: A retrospective study," Am. Surg., vol. 64, pp. 397–400. Discussion 400–401, 1998.
  14. R. Green, D. Dafoe, and T. Raffin, "Necrotizing fasciitis," Chest, vol. 110, pp. 219–229, 1996.
  15. J. Majeski and E. Majeski, "Necrotizing fasciitis: Improved survival with early recognition by tissue biopsy and aggressive surgical treatment," South Med. J., vol. 90, pp. 1065–1068, 1997.
  16. P. Dahl, C. Perniciaro, K. Holmkvist, M. O’Connor, and L. Gibson, "Fulminant group a streptococcal necrotizing fasciitis: Clin- ical and pathologic findings in 7 patients," J. Am. Acad. Dermatol., vol. 47, pp. 489–492, 2002.
  17. T. Andreasen, S. Green, and B. Childers, "Massive infectious soft- tissue injury: Diagnosis and management of necrotizing fasciitis and purpura fulminans," Plast. Reconstr. Surg., vol. 107, pp. 1025–1035, 2001.
  18. C. Wong, L. Khin, K. Heng, K. Tan, and C. Low, "The LRINEC (Laboratory Risk Indicator For Necrotizing Fasciitis) score: A tool for distinguishing necrotizing fasciitis from other soft tissue infections," Crit. Care Med., vol. 32, pp. 1535–1541, 2004.
  19. D. Morrison, M. Blaivas, and M. Lyon, "Emergency diagnosis of fournier’s gangrene with bedside ultrasound," Am. J. Emerg. Med., vol. 23, pp. 544–547, 2005.
  20. R. Rodriguez, R. Abdullah, and R. Miller, "A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis," Am. J. Emerg. Med., vol. 24, pp. 58–61, 2006.
  21. C. Wong, H. Chang, S. Pasupathy, L. Khin, J. Tan, and C. Low, "Necrotizing fasciitis: Clinical presentation, microbiology and determinants of mortality," J. Bone Joint Surg. Am., vol. 85, pp. 1454–1460, 2003.
  22. C. Liao, Y. Lee, Y. Su, and C. Chuang, "Validation of the laboratory risk indicator for necrotizing fasciitis (LRINEC) score for early diagnosis of necrotizing fasciitis," Tzu. Chi. Medical Journal, vol. 24, pp. 73-76, 2012.


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