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Plasma Membrane-derived Extracellular Vesicles (PMEVs) are membrane-coated vesicles of diameter 0.1 to 1.5µm, carrying various proteins inherent in their parental cells. PMEVs are released when cells undergo activation/apoptosis via blebbing and shedding and have a function in intercellular communication. Exposition of phosphatidylserine (PS) on the outer membrane leaflet that mark them as a biologically distinct entity could also explain a role for PMEVs in phagocytosis and thrombosis. The purpose of this review is to outline and discuss some of the functions of PMEVs in detail to throw more light on its biological effects as more research delve into emerging therapies targeting the microvesicle communication system. The role of PMEVs as a differentiation agent and therefore its possible use in differentiation therapy is discussed. In some experiments, the myeloid differentiating agents all trans retinoic acid (ATRA), phorbol 12-myristate 13-acetate (PMA) and histamine, which inhibit promonocyte proliferation, induced an intracellular Ca2+-mediated PMEV release from HL-60 promonocytes. These PMEVs caused HL-60 cells to enter G0/G1 cell cycle arrest and induce terminal monocyte-to-macrophage differentiation through TGF-β1 mediation. The review also discusses the relationship between PMEVs and diseases where it is known that patients with certain inflammatory diseases show increased PMEV levels in the plasma. The review conclude on the fact that PMEVs have a lot of biological functions that are beneficial to the physiological functions in humans and therefore more work is required to elucidate their composition and the mechanisms involved in exertion of their effects.
This study contributes to the existing literature by addressing some aspects of extracellular vesicle release as well as their functions. The topic is of general interest and will be beneficial to potential readers who would want to clarify types of plasma extracellular vesicles, their functions or pathological effects.
B. György, T. G. Szabó, M. Pásztói, Z. Pál, P. Misják, and B. Aradi, "Membrane vesicles, current state-of-the-art: Emerging role of extracellular vesicles," Cell Mol. Life Sci., vol. 68, pp. 2667-2688, 2011.
J. J. Jimenez, W. Jy, L. M. Mauro, C. Soderland, L. L. Horstman, and Y. Ahn, "Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis," Thromb Res., vol. 109, pp. 175-180, 2003.
R. Nieuwland and A. Sturk, Platelet-derived microparticles. London: Academic Press, Elsevier Science, 2002.
A.-S. Anne, "Leukocyte-derived microparticles in vascular homeostasis," Circulation Research, vol. 110, pp. 356 – 369, 2012.
H. W. Jörg Distler, S. David Pisetsky, C. Lars Huber, R. Joachim Kalden, G. Steffen, and D. Oliver, "Microparticles as regulators of inflammation: Novel players of cellular crosstalk in the rheumatic diseases," Arthritis & Rheumatism, vol. 52, pp. 3337–3348, 2005.
A. Julio Chirinos, A. Gustavo Heresi, V. Hermes, J. Wenche, J. Joaquin Jimenez, and A. Eugene, "Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism," Journal of the American College of Cardiology, vol. 45, pp. 1467–1471, 2005.
E. Hind, S. Heugh, E. A. Ansa-Addo, S. Antwi-Baffour, S. Lange, and J. N. Inal Biochem, "Red-cell derived plasma membrane-derived vesicles: Result variability and standardizatio," Biophys. Res. Commun., vol. 280, pp. 818–823, 2010.
S. B. Forlow, R. P. McEver, and M. U. Nollert, "Leukocyte–leukocyte interactions mediated by platelet microparticles under flow," Blood, vol. 95, pp. 1317–1323, 2000.
C.N. I. Del Conde, P. Shrimpton Thiagarajan, and J. A. Lopez, "Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation," Blood, vol. 106, pp. 1604-1611, 2005.
U. Rauch, D. Bonderman, B. Bohrmann, J. J. Badimon, J. Himber, and M. A. Riederer, "Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor," Blood, vol. 96, pp. 170-175, 2000.
P. Thomas, H. Sigrún, F. Philippe Devaux, and M. Gerrit Van, "Lipid distribution and transport across cellular membranes," Cell & Developmental Biology, vol. 12, pp. 139–148, 2001.
B. Lentz, "Exposure of platelet membrane phosphatidylserine regulates blood coagulation," Prog. Lipid. Res., vol. 42, pp. 423-438, 2003.
V. Muralidharan-Chari, J. Clancy, C. Plou, M. Romao, P. Chavrier, G. Raposo, and C. D’Souza-Schorey, "ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles," Curr. Biol., vol. 19, pp. 1875-1885, 2009a.
N. Chazal and D. Gerlier, "Virus entry, assembly, budding, and membrane rafts," Microbiol. Mol. Biol. Rev., vol. 67, pp. 226-237, 2003.
R. C. Taylor, S. P. Cullen, and S. J. Martin, "Apoptosis: Controlled demolition at the cellular level," Nat. Rev. Mol. Cell Biol., vol. 9, pp. 231-241, 2008.
M.-C. Vandhana, W. James Clancy, S. Alanna, and D. S.-S. Crislyn, "Microvesicles: Mediators of extracellular communication during cancer progression," Journal of Cell Science, vol. 123, pp. 1603-1611, 2010.
D. Corbeil, K. Roper, C. A. Fargeas, A. Joester, and W. B. Huttner, "Prominin: A story of cholesterol, plasma membrane protrusions and human pathology," Traffic, vol. 2, pp. 82-91, 2001.
T. Clotilde, Z. Laurence, and A. Sebastian, "Exosomes: Composition, biogenesis and function," Nature Reviews Immunology, vol. 2, pp. 569–579, 2002.
R. Graça and S. Willem, "Extracellular vesicles: Exosomes, microvesicles, and friends," JCB, vol. 200, pp. 4373-383, 2012.
R. J. Berckmans, R. Nieuwland, A. N. Böing, F. P. Romijn, C. E. Hack, and A. Sturk, "Cell-derived microparticles circulate in healthy humans and support low-grade thrombin generation," J. Thromb Haemost., vol. 85, pp. 639-46, 2001.
A. Phillip Owens III, M. Nigel, W. Christian, and M. Sebastian, "Microparticles in hemostasis and thrombosis," Circulation Research, vol. 108, pp. 1284 –1297, 2011.
C. M. Boulanger, A. Scoazec, T. Ebrahimian, P. Henry, E. Mathieu, and A. Tedgui, "Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction," Circulation Research, vol. 104, pp. 2649-2652, 2001.
D. Boettner, C. D. Huston, A. S. Linford, S. N. Buss, E. Houpt, and N. E. Sherman, "Entamoeba histolytica phagocytosis of human erythrocytes involves PATMK, a member of the transmembrane kinase family," PloS Pathog., vol. 4, p. 122-133, 2008.
M. Baj-Krzyworzeka, M. Majka, D. Pratico, J. Ratajczak, G. Vilaire, and J. Kijowski, "Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells," Exp. Hematol., vol. 30, pp. 450-459, 2002.
A. Janowska-Wieczorek, M. Majka, J. Kijowski, M. Baj-Krzyworzeka, R. Reca, and A. R. Turner, "Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment," Blood, vol. 98, pp. 3143-3149, 2001.
J. J. Italiano, A. Mairuhu, and R. Flaumenhaft, "Clinical relevance of microparticles from platelets and megakaryocytes," Curr. Opin. Hematol., vol. 17, pp. 578-584, 2010.
M. O. Li, M. R. Sarkisian, W. Z. Mehal, P. Rakic, and R. A. Flavell, "Phosphatidylserine receptor is required for clearance of apoptotic cells," Science, vol. 302, pp. 1560-1563, 2003.
J. Huber, A. Vales, G. Mitulovic, M. Blumer, R. Schmid, and J. L. Witztum, "Oxidized membrane vesicles and blebs from apoptotic cells contain biologically activate oxidized phospholipids that induce monocyte–endothelial interactions," Arterioscler Thromb Vasc Biol., vol. 22, pp. 101-107, 2002.
A. J. Nauta, L. A. Trouw, M. R. Daha, O. Tijsma, R. Nieuwland, and W. J. Schwaeble, "Direct binding of C1q to apoptotic cells and cell blebs induces complement activation," Eur. J. Immunol., vol. 32, pp. 1726-1736, 2002.
M. Diamant, R. Nieuwland, R. F. Pablo, A. Sturk, J. W. Smit, and J. Radder, "Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes," Circulation Research, vol. 106, pp. 2442-2447, 2002.
S. Antwi-Baffour, S. Kholia, K. D. A. Yushau, E. Ansa-Addo, D. Stratton, S. Lange, and J. M. Inal, "Human plasma membrane-derived vesicles inhibits the phagocytosis of apoptotic cells – possible role in SLE," Biochem. Biophys. Res. Commun., vol. 398, pp. 278-283, 2010.
O. Gasser and J. A. Schifferli, "Activated polymorphonuclear neutrophils immunol," Dis., vol. 22, pp. 572–574, 2004.
D. Laurent and W. Zhen Yi, "All trans retinoic acid in acute promyelocytic leukemia," Oncogene, vol. 20, pp. 7140-7145, 2001.
M. S. Tallman and J. K. Altman, "Curative strategies in acute promyelocytic leukemia," Hematology Am. Soc. Hematol. Educ. Program, vol. 1, pp. 391–399, 2008.
I. C. N. Del Conde, P. Shrimpton Thiagarajan, and J. A. Lopez, "Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation," Blood, vol. 106, pp. 1604-1611, 2005.
H. Iland and J. Seymour, "Role of arsenic trioxide in acute promyelocytic leukemia," Curr. Treat. Options Oncol., vol. 14, pp. 170-184, 2013.
N. Bréchot, E. Gomez, M. Bignon, J. Khallou-Laschet, M. Dussiot, and A. Cazes, "Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice," Plos One, vol. 3, p. e3950, 2008.
E. Carole, D. Peter Katsikis, and E. Jérôme, "Neutrophil apoptosis during viral infections," Open Virol. J., vol. 3, pp. 52–59, 2009.
A. Lucas and D. Greaves, "Atherosclerosis: Role of chemokines and macrophages," Expert. Rev. Mol. Med., vol. 3, pp. 1–18, 2001.
V. Combes, N. Coltel, M. Alibert, M. Van Eck, C. Raymond, and I. Juhan-Vague, "ABCA1 gene deletion protects against cerebral malaria potential pathogenic role of microparticles in neuropathology," Am. J. Patho., vol. 166, pp. 295-302, 2005.
A. Piccin, W. G. Murphy, and O. P. Smith, "Circulating microparticles: Pathophysiology and clinical implications," Blood Rev., vol. 21, pp. 157-171, 2007.
M. J. Vanwijk, E. Svedas, K. Boer, R. Nieuwland, E. Vanbavel, and K. R. Kublickiene, "Isolated microparticles, but not whole plasma, from women with preeclampsia impair endothelium-dependent relaxation in isolated myometrial arteries from normal pregnant women," Am. J. Obstet. Gynecol., vol. 187, pp. 1686-1693, 2002.