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Cancers Review

December 2014, Volume 1, 2, pp 45-51

Role of Iron Metabolism in Breast Cancer Patients

Rakesh Dhankhar

,

Adarsh C

,

Kiran Dahiya

,

Veena Singh Ghalaut

,

Nityasha .

,

Anil Kumar Dhull

,

Anil Khurana

Rakesh Dhankhar 1
Adarsh C 2
Kiran Dahiya 3

Veena Singh Ghalaut 4
Nityasha . 5
Anil Kumar Dhull 6
Anil Khurana 7

  1. Professor, Department of Radiotherapy, Pt. B.D.S. PGIMS, Rohtak, Haryana, India 1

  2. Ex-resident, Department of Radiotherapy, Pt. B.D.S. PGIMS, Rohtak, Haryana, India 2

  3. Professor, Department of Biochemistry, Pt. B.D.S. PGIMS, Rohtak, Haryana, India 3

  4. Senior Professor and Head, Department of Biochemistry, Pt. B.D.S. PGIMS, Rohtak, Haryana, India 4

  5. Professor, Department of Surgery, Pt. B.D.S. PGIMS, Rohtak, Haryana, India 5

  6. Medical Officer, Department of Radiotherapy, Pt. B.D.S. PGIMS, Rohtak, Haryana, India 6

  7. Medical Officer, Department of Radiotherapy, Pt. B.D.S. PGIMS, Rohtak, Haryana, 7

Pages: 45-51

DOI: 10.18488/journal.95/2014.1.2/95.2.45.51

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Abstract:

Iron metabolism is closely related to carcinogenesis. In this study, iron, ferritin and TIBC were analysed in 30 patients of early stage, 30 of advanced stage breast carcinoma before and after treatment and the results were compared with 30 healthy controls. The levels of all the three parameters were found to be significantly higher in breast cancer patients as compared to healthy controls and patients with advanced disease showed greater values as compared to early stage disease. These levels decreased after treatment and the difference was more significant in patients with complete response. Serum analyses of iron, ferritin and TIBC may help in assessing the severity and prognosis of the disease.
Contribution/ Originality
This study contributes in the existing literature regarding association of iron metabolism and carcinogenesis. The principal role of iron profile analysis may be in asessing the severity and monitoring the treatment of breast cancer patients.

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Reference:

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