Contact Us

For Marketing, Sales and Subscriptions Inquiries
2637 E Atlantic Blvd #43110
Pompano Beach, FL 33062
USA

Conference List

Serum Lipid Profile and Leptin Levels in Asthmatic Libyan Children


Pages: 93-98

DOI: 10.18488/journal.9/2016.3.8/9.8.93.98

Share :

Article History:

Received: 09 June, 2016
Revised: 01 October, 2016
Accepted: 19 October, 2016
Published: 02 November, 2016


Abstract:

Aim:To study lipid profile and leptin levels in non-obese Libyan children with asthma.. Materials and Methods:70 Libyan children from Pediatrics Department, Faculty of Medicine, Benghazi University, Benghazi, Libya were included for the present study (from 2013 to 2014). Group I formed the normal control group (N: 30 Children) and  Group II is 40  Libyan children with asthma. Their age group varied from 4 to 12 years old. Serum lipid profile and leptin were measured by routine standard methods. Results and discussion: The Libyan children with asthma showed an increase in serum total cholesterol, LDL cholesterol, VLDL cholesterol, HDL cholesterol and triglycerides. Serum Leptin levels did not show marked changes between the two groups. The presence of hypercholesterolemia could be a triggering factor for generation of proinflammatory response in these children. Though leptin levels did not show marked response further studies may be necessary to study the role of leptin in obese asthmatic Libyan children.
Contribution/ Originality
This paper tries to bring out the relationship between serum leptin and lipid levels in non-obese asthmatic Libyan children and relate it to serum leptin level.

Keywords:

Asthma, Lipid profile, Leptin, Proinflammatory response, Libyan children.

Video:

Reference:

  1. M. J. Van Rooy, "Pretorius E1. Obesity, hypertension and hypercholesterolemia as risk factors for atherosclerosis leading to ischemic events," Current Medicinal Chemistry, vol. 21, pp. 2121-2129, 2014.
  2. B. Al-Shawwa, N. Al-Huniti, G. Titus, and M. Abu-Hasan, "Hypercholesterolemia is a potential risk factor for asthma," Journal of Asthma, vol. 43, pp. 231-233, 2006.
  3. A. Bedir, M. Topbas, F. Tanyeri, M. Alvur, and N. Arık, "Leptin might be a regulator of serum uric acid concentrations in humans," Japanese Heart Journal, vol. 44, pp. 527-536, 2003.
  4. K. Matsuda, Y. Nishi, Y. Okamatsu, M. Kojima, and T. Matsuishi, "Ghrelin and leptin: A link between obesity and allergy?," Journal of Allergy and Clinical Immunology, vol. 117, pp. 705-706, 2006.
  5. A. Sood, E. S. Ford, and C. A. Camargo, "Association between leptin and asthma in adults," Thorax, vol. 61, pp. 300-305, 2006.
  6. K. Y. Stokes, D. Cooper, A. Tailor, and D. N. Granger, "Hypercholesterolemia promotes inflammation and microvascular dysfunction: Role of nitric oxide and superoxide," Free Radical Biology and Medicine, vol. 33, pp. 1026–1036, 2002.
  7. R. Scalia, J. Z. Appel, and A. M. Lefer, "Leukocyte-endothelium interaction during the early stages of hypercholesterolemia in the rabbit: Role of P-selectin, ICAM-1, and VCAM-1," Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 18, pp. 1093–1100, 1998.
  8. G. Engström, P. Lind, B. Hedblad, L. Stavenow, L. Janzon, and F. Lindgärde, "Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men," Circulation, vol. 105, pp. 2632–2637, 2002.
  9. Z. Doniec, K. Pierzchala-Koziec, and W. Tomalak, "Serum level of leptin and neuropeptide Y in children with mild asthma," Pneumonologia Alergologia Polska, vol. 72, pp. 9-13, 2004.
  10. F. Erela, M. Guleca, O. Kartal, Z. Caliskanera, S. Ozturka, and H. Yamanb, "Serum leptin levels and lipid profiles in patients with allergic rhinitis and mild asthma," Allergol Et Immunopathol, vol. 35, pp. 232-238, 2007.
  11. N. P. Jayasekera, T. P. Toma, A. Williams, and K. Rajakulasingam, "Mechanisms of immunotherapy in allergic rhinitis," Biomed Pharmacother, vol. 61, pp. 29-33, 2007.
  12. G. Fantuzzi, "Adipose tissue, adipokines, and inflammation," Journal of Allergy and Clinical Immunology, vol. 115, pp. 911-919, 2005.

Statistics:

Google Scholor ideas Microsoft Academic Search bing Google Scholor

Funding:

This study received no specific financial support.

Competing Interests:

The authors declare that they have no competing interests.

Acknowledgement:

All authors contributed equally to the conception and design of the study.

Related Article