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50th International Scientific Conference on Sport, Medical and Health Sciences Vennue: Hotel Grand Flora Dubai, UAE Al- Rigga Road Deira , Near Al-Rigga Metro station , Deira Dubai UAE Date: 20-Dec-2018 More Details
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Introduction: A causal relationship between the thymus gland and myasthenia gravis (MG) has been assumed for decades. However, this relationship is still a matter of conjecture and speculations and awaits definitive proof. Recently, myoid cells have been considered as effectors in the pathogenesis of MG as well as thymic enlargement (thymolipoma, true thymic hyperplasia). Material and methods: we report a retrospective study about 6 cases of thymic enlargement with 4 cases of true thymic hyperplasia (TTH) and 2 cases of thymolipoma (TL). Aim: Our objective is to discuss the role of myoid cells in the pathogenesis of MG associated with thymic enlargement. Results: The majority of our patients were men with a sex ratio of 4/2. Only 2 patients had a past medical history consistent for MG. Myoid cells were found in all cases. Conclusion: Through our small study, the implication of myoid cells in the pathogenesis of the association MG-TL or TTH remains unproved.
This study contributes in the existing literature by enriching our knowledge about the pathogenesis of myasthenia gravis.
O. Archer and J. Pierce, "Role of thymus in development of the immune response," Fed. Proc., pp. 20-26, 1961.
G. Gronseth and R. Barohn, "Practice parameter, thymectomy for auto-immune myasthenia gravis," Neurology, vol. 55, pp. 7-15, 2000.
R. Mantegazza, F. Baggi, P. Bernasconi, C. Antozzi, P. Confalonieri, L. Novellino, L. Spinelli, M. Ferro, E. Beghi, and F. Cornelio, "Video-assisted thoracoscopic extended themectomy and extended transsternel themectomy ( T-3b ) in non thymomatous myasthenia gravis patients: Remission after 6 years of follow-up," J Neurol Sci., vol. 212, pp. 31-36, 2003.
A. Marx, A. Willisch, A. Schultz, S. Gattenlohner, R. Nenninger, and H. Hermelink, "Pathogenesis of myasthenia gravis," Virchows Arch., vol. 430, pp. 355-364, 1997.
J. Pal, C. Rozsa, S. Komoly, and Z. Illes, "Clinical and biological heterogeneity of autoimmune myasthenia gravis," J Immunoneurol., vol. 231, pp. 43-54, 2011.
S. Ragheb and R. Lisak, "The thymus and Myasthenia gravis," Chest Surg. Clin. N. Am., vol. 11, pp. 311-27, 2001.
G. Sims, H. Shiono, N. Willcox, and D. Stott, "Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in Myasthenia gravis," Journal of Immunology, vol. 167, pp. 1935-1944, 2001.
A. Vincent, "Unravelling the pathogenesis of myasthenia gravis," Nat Rev Immunol., vol. 2, pp. 797-804, 2002.
A. Wakkach, T. Guyon, C. Bruand, S. Tzarlos, S. Kaminsky, and S. Aknin, "Expression of acetylcholine receptor genes in human thymic epithelial cells: Implication for Myasthenia gravis," J Immunol., vol. 175, pp. 3752-3760, 1996.