This work deals with the synthesis and cytotoxicity of some heterocyclic compounds starting from 2-acetylfuran. The title compound was used for the synthesis of thiophene derivative 3 through its reaction with elemental sulfur and ethyl cyanoacetate. Compound 3 was used for the synthesis of thiophene, thieno[2,3-c]pyrazole, thieno[2,3-d]pyrimidine and pyridine derivatives through its reaction with different reagents. The newly synthesized compounds were screened through three cancer cell lines. Compound 13b showed the highest potency among the synthesized compounds.
This study contributes in the existing literature that thiophene
derivatives can be produced from simple commercially available starting
materials. The reactions of the produced thiophene derivative with
different reagents gave both pyrazole and pyridine derivatives. The
cytotoxicity of the produced products gave that some compounds with high