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Synthesis and Cytotoxicity of Thiophene, Thieno[2,3-C]Pyrazole, Thieno[2,3-D]Pyrimidine and Pyridine Derivatives Derived from 2-Acetylfuran

Abeer A. Mohamed

,

Amr S. Abouzied

,

Faten I. Hamed

Abeer A. Mohamed 1

Amr S. Abouzied 2
Faten I. Hamed 3

  1. National Organization for Research and control of Biologicals, Giza, Egypt 1

  2. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, Kingdom of Saudi Arabia; National Organization for Drug Control & Research, Giza, Egypt 2

  3. National Organization for Drug Control & Research, Giza, Egypt 3

Pages: 1-14

DOI: 10.18488/journal.64.2017.51.1.14

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Article History:

Received: 31 March, 2017
Revised: 02 May, 2017
Accepted: 24 May, 2017
Published: 13 June, 2017


Abstract:

This work deals with the synthesis and cytotoxicity of some heterocyclic compounds starting from 2-acetylfuran. The title compound was used for the synthesis of thiophene derivative 3 through its reaction with elemental sulfur and ethyl cyanoacetate. Compound 3 was used for the synthesis of thiophene, thieno[2,3-c]pyrazole, thieno[2,3-d]pyrimidine and pyridine derivatives through its reaction with different reagents. The newly synthesized compounds were screened through three cancer cell lines.  Compound 13b showed the highest potency among the synthesized compounds.

Contribution/ Originality
This study contributes in the existing literature that thiophene derivatives can be produced from simple commercially available starting materials. The reactions of the produced thiophene derivative with different reagents gave both pyrazole and pyridine derivatives. The cytotoxicity of the produced products gave that some compounds with high potency.

Keywords:

2-Acetylfuran, Thiophene, Pyridine, Pyrimidine, Pyrazole, Cytotoxicity.

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Funding:

This study received no specific financial support.

Competing Interests:

The authors declare that they have no competing interests.

Acknowledgement:

All authors contributed equally to the conception and design of the study.

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