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Genes Review

March 2016, Volume 2, 1, pp 12-15

Scedosporium Prolificans, An Unusual Cause of Frontal Abscess

Beena .


Sridhar Honappa


Naik Shalini Ashok

Beena . 1 ,

Sridhar Honappa 2
Naik Shalini Ashok 1 
  1. Department of Microbiology, M.S.Ramaiah Medical College and Teaching Hospital, Bangalore 1

  2. Department of Pathology, M.S. Ramaiah Medical College and Teaching Hospital, Bangalore 2

Pages: 12-15

DOI: 10.18488/journal.103/2016.2.1/

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Scedosporium infections have become one of the most common cause of deep mold infections. It has also become a potentially dangerous causative agent of local and invasive infections in immunocompromised and occasionally in immunocompetent patients. It exhibits intrinsic resistance to many antifungals making the treatment difficult, thereby increasing the mortality. We present a case of an immunocompetent patient who came with a swelling on the left upper eyelid with a discharging sinus. A diagnosis of frontal lobe abscess was made and the mucopurulent discharge from the sinus was sent to the microbiology laboratory to know the etiology. The KOH wet mount of this discharge showed the presence of septate hyphal elements and the fungal culture yielded the growth of Scedosporium prolificans.The patient was treated with intravenous voriconazole to which he showed a favourable response.

Contribution/ Originality
This study contributes in the existing literature with various clinical manifestations of Scedosporium like osteomyelitis, lung infection and infection in the  transplant patients. This study is one of very few studies  as scedosporium causing frontal lobe abscess…is rare. The paper's primary contribution is finding out the various causes of infections manifesting as a central venous system infection. This study documents that Scedosporium can enter the CNS through nasal septum and can be treated with voriconazole. 




  1. J. Perfect and W. Schell, "The new fungal opportunists are coming," Clin. Infect Dis., vol. 22, pp. 112-118, 1996.
  2. A. Kesson, M. Bellemore, T. O’Mara, D. Ellis, and T. Sorrell, "Scedosporium prolificans osteomyelitis in an immunocompetent child treated with a novel agent, hexadecylphospocholine (Miltefosine) in combination with terbinafine and voriconazole: A case report," Clin. Infect Dis., vol. 48, pp. 1257–1261, 2009.
  3. J. Berenguer, J. Rodriguez-Tudela, C. Richard, and M. Alvarez, "Deep infections caused by scedosporium prolificans, a report on 16 cases in Spain and review of the literature. Scedosporium prolificans Spanish study group," Medicine, vol. 76, pp. 256-65, 1997.
  4. G. S. De Hoog, F. Marvin Sikkema, and G. Lahpoor, "Ecology and physiology of the emerging opportunistic fungi pseudoallescharia boydii and scedosporium prolificans," Mycoses, vol. 37, pp. 71-78, 1994.
  5. M. Monika, K. Ravinder, and A. Shweta, "A case of scedosporium prolificans osteomyelitis in an immunocompetent child misdiagnosed as tubercular osteomyelitis," Indian J. Dermatol., vol. 58, pp. 80–81, 2013.
  6. C. Louise, S. Denis, T. Karin, and S. Monica, "Infection with Scedosporium apiospermum and S. Prolificans, Australia," Emerg. Infect Dis., vol. 13, pp. 1170- 1177, 2007.
  7. M. Patricia, M. Marin, P. Tornero, R. P. Martin, M. Rodriguez, and E. Bouza, "Successful outcome of scedosporium apiospermum disseminated infection treated with voriconazole in a patient receiving corticosteroid therapy," Clin. Infect Dis., vol. 31, pp. 1499-1501, 2000.
  8. J. Rodriguez-Tudela, J. Berenguer, J. Guarro, A. Kantarcioglu, R. Horre, and G. De Hoog, "Epidemiology and outcome of scedosporium prolificans infection, a review of 162 cases," Med. Mycol., vol. 47, pp. 359-370, 2009.
  9. S. Gluckman, K. Ries, and E. Abrutynm, "Allescheria (Petriellidium) boydii sinusitis in a compromised host," J. Clin. Microbiol., vol. 5, pp. 481-484, 1977.
  10. F. H. Andrew, R. C. Jose, A. B. Michelle, and C. N. Aran, "Combination  antifungal therapy in the treatment of scedosporium apiospermum central nervous system infections," Case Reports in Infectious Diseases, 2013.


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