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Journal of Diseases

June 2018, Volume 5, 2, pp 33-42

Differential Responses to Cognitive Behavioral Therapy and Pharmacotherapy Versus Combined Therapy in Young Adolescents with Depression

Fereshte Shakibai


Maryam Esmaeili


Nooshin Basiri

Fereshte Shakibai 1
Maryam Esmaeili 2
Nooshin Basiri 3

  1. Associate Professor of Pediatric Psychiatry, School of Medicine, Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 1

  2. Assailant Professor, Department of Psychology, Faculty of Education and Psychology, University of Isfahan, Isfahan, Iran 2

  3. PhD Candidate of Clinical Psychology, School of Clinical Psychology, University of Shiraz, Shiraz, Iran 3

Pages: 33-42

DOI: 10.18488/journal.99.2018.52.33.42

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Article History:

Received: 24 May, 2018
Revised: 02 July, 2018
Accepted: 15 August, 2018
Published: 10 October, 2018


Background: Treatment of patients with major depression involves some problems and, an effective therapy, is still a debatable issue. The goal of this review was to provide a comprehensive survey on comparing three methods of Cognitive Behavioral Therapy, pharmacotherapy and combined therapy on treatment of depressed adolescents. Material and methods: this study was a randomized clinical trial with follow- up which was conducted in Isfahan city (2015). The statistical population included 330 middle school students (aged 13- 16 years) who had the criteria of depression disorder. Then 120 girls and boys were selected via cluster sampling. After that, they divided into 4 groups (3 experimental groups and 1 control group). 4 month after finishing the intervention, all groups were followed by the project. The research tool was the children's depression Inventory (CDI). Results: the results showed that all of the 3 experimental groups were significantly effective in the treatment of depression (p<00.1). In the post-test stage, the combination of pharmacotherapy and CBT, pharmacotherapy, CBT respectively were effective (p<00.0). But the findings illustrate that in the follow- up stage cognitive behavioral therapy had a long-term effect in compare to pharmacotherapy. Conclusion: at last the research results show significant efficacy of all three methods, with different priorities effect, at various stages, on improving the criteria for depression in adolescents.
Contribution/ Originality
This study contributes to the existing literature to clarify the best therapy for depressive mood in adolescents. This study uses a new estimation methodology for comparative studies. This study originates a new formula for two kinds of therapy. This study is one of the very few studies which have investigated the differentiated responses to different therapies. The paper contributes the first logical analysis that why these therapies can be different. The paper's primary contribution is finding that in which condition we can use 3 different therapy. This study documents the proven sources in the use of various therapeutic approaches.


Cognitive behavioral therapy, Pharmacotherapy, Depression, Students, Cognition, behavior



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The authors would like to thank all Participants of this study and Also Dr. Raziye Izadi for their assistance in running the project.

Competing Interests:

The authors declare that they have no competing interests.


F.SH contributed in the concepts, design and statistical analysis and also she is the guarantor, agreed for all aspects of the work. M.E contributed in the Definition of intellectual content, Clinical studies & Data acquisition and agreed for all aspects of the work. N.B contributed in Literature search, Manuscript preparation, Manuscript editing, Manuscript review and agreed for all aspects of the work. F.Y contributed in Experimental studies & Data analysis and agreed for all aspects of the work

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