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Journal of Cells

June 2017, Volume 2, 1, pp 6-14

Gender as Determinant of the Effect of Yeast Selenium on CD4 T Cells Count Among HIV 1 Positive Children

Samwel Boaz Otieno

Samwel Boaz Otieno 1

  1. Ministry of Agriculture, Livestock and Fisheries Cathedral Road, Nairobi, Kenya 1

on Google Scholar
on PubMed

Pages: 6-14

DOI: 10.18488/journal.97.2017.21.6.14

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Article History:

Received: 29 March, 2017
Revised: 05 July, 2017
Accepted: 13 July, 2017
Published: 27 July, 2017


Abstract:

Background Sex steroid estrogens (E2) have been observed to have synergistic effect on activity of GSH-px on pre-menopausal females taking selenium. GSH-px activity is correlated to CD4 T cell count in HIV positive patients. However no study has been done to determine gender differentiated effect of yeast selenium intake on CD4 T cell count of pre-puberty male and female children. Methods In the study 25 girls and 25 boys  HIV-1 positive on WHO stage three and below were given 50μg yeast selenium and blood samples taken at  zero, three and six months intervals in EDTA vacuutainers. The blood samples were analyzed for CD4 T cell count by ELISA. Results: No significant CD4 T cell count change in the test group = -2.943,p< 0.05 compared to the matched controls t = -1.258 p> 0.05. CD4 T cell count increased among all age groups on test 3-5years (+ 267.1),5-8 years( +200.3)  9-15 years  (+71.2) cells/mm3  and while in matched controls there was a decrease in all age groups 3-5 years(-71),5-8 years (-125) and 9-13years(-10.1)cells/mm3  . No significant difference was observed in CD4 T cell count between boys and Girls {F (df 5, 81) = 1.379 p=0.241} between girls {F ( df 2,32) = 1.531, p= 0.232} and between boys { F ( df 2, 49) = 1.040, p= 0.361} on selenium and between boys and girls {F (df 5, 86) = 1.168, p= 0.332} on control at six months. Conclusion It can be concluded that there was significant increase in CD4 T cell count among the children on selenium, but no significant difference in the effect of selenium on CD4 T cell count between pre-menopausal females and male.

Contribution/ Originality
This study contributes to understanding of the effects of selenium administration to HIV positive children. The yeast selenium provided is commonly available in chemists as nutritional supplements. From this study it is observed that selenium supplementation leads to increase in weight gain and equally increase in CD4 cell count (p< 0.05) between baseline and six month sampling, and delayed progression of the AIDS patients as seen by improvement in WHO clinical staging, and the WAZ-Score.  

Keywords:

Selenium, Gender, Estrogens, HIV, Sex, Age.

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Funding:

This study received no specific financial support.

Competing Interests:

The author declares that there are no conflicts of interests regarding the publication of this paper.

Acknowledgement:


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