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49th International Scientific Conference on Sport, Medical and Health Sciences Vennue: Hotel Istana Kuala Lumpur City Centre 73 Jalan Raja Chulan, Kuala Lumpur, 50200, Malaysia Date: 04-Sep-2018 More Details
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50th International Scientific Conference on Sport, Medical and Health Sciences Vennue: Hotel Grand Flora Dubai, UAE Al- Rigga Road Deira , Near Al-Rigga Metro station , Deira Dubai UAE Date: 20-Dec-2018 More Details
Background: The causality role of different immune phenotype in IR developing among chronic heart failure (CHF) subjects has not determined obviously. The aim of the study was to assess relationship between IR and immune phenotype of circulating endothelial-derived microparticles (EMPs) in patients with CHF. Methods: The study retrospectively involved 300 CHF patients aged 48 to 62 years. All the patients have given written informed consent for participation in the study. Biomarkers were measured at baseline of the study. Results: These were not significant differences between both cohort patients in EMPs labeled as CD144+/CD31+, CD144+/annexin V+, and CD62E+ microparticles. Higher concentrations of CD144+/CD31+/annexin V+ EMPs and CD31+/annexin V+ EMPs were found in IR subjects when compared with none IR patients. Using multivariate logistic regression analyses, we found that HOMA-IR (OR = 1.14, 95% CI=1.08-1.21, P = 0.001), NT-proBNP (OR = 1.07, 95% CI=1.04-1.10, P = 0.001), hs-CRP (OR = 1.04, 95% CI=1.02-1.07, P = 0.001), and NYHA class (OR = 1.03, 95% CI=1.01-1.05, P = 0.001) were predictors for increased CD31+/annexin V+ EMPs. Therefore, HOMA-IR (OR = 1.10, 95% CI=1.05-1.17, P = 0.001), NT-proBNP (OR = 1.08, 95% CI=1.04-1.12, P = 0.001), and NYHA class (OR = 1.05, 95% CI=1.02-1.09, P = 0.001) significantly predicted elevation of CD144+/CD31+/annexin V+ EMPs. Conclusion: we found that IR remains statistically significant predictor for increased apoptotic-derived EMPs labelled as CD144+/CD31+/annexin V+ and CD31+/annexin V+ EMPsin none-diabetic patients with CHF patients and that these findings reflect exiting impaired phenotype of circulating EMPs in this patient population.
The paper’s primary contribution is finding that insulin resistance may predict being of impaired phenotype of circulating endothelial-derived microparticles among none-diabetic patients with chronic heart failure.
M. M. Redfield, S. J. Jacobsen, J. J. C. Burnett, D. W. Mahoney, K. R. Bailey, and R. J. Rodeheffer, "Burden of systolic and diastolic ventricular dysfunction in the community: Appreciating the scope of the heart failure epidemic," JAMA, vol. 289, pp. 194–202, 2003.
R. J. Goldberg, F. A. Spencer, C. Farmer, T. E. Meyer, and S. Pezzella, "Incidence and hospital death rates associated with heart failure: A community-wide perspective," Am. J. Med., vol. 118, pp. 728–734, 2005.
V. Baliga and R. Sapsford, "Diabetes mellitus and heart failure – an overview of epidemiology and management," Diab. Vasc. Dis. Res., vol. 6, pp. 164–171, 2009.
M. Bastien, P. Poirier, I. Lemieux, and J. P. Després, "Overview of epidemiology and contribution of obesity to cardiovascular disease," Prog. Cardiovasc Dis., vol. 56, pp. 369-381, 2014.
M. R. MacDonald, M. C. Petrie, N. M. Hawkins, J. R. Petrie, M. Fisher, R. McKelvie, D. Aguilar, H. Krum, and J. J. V. McMurray, "Diabetes, left ventricular systolic dysfunction, and chronic heart failure," Eur. Heart J., vol. 29, pp. 1224–1240, 2008.
M. Chinali, S. W. Joffe, G. P. Aurigemma, R. Makam, T. E. Meyer, and R. J. Goldberg, "Risk factors and comorbidities in a community-wide sample of patients hospitalized with acute systolic or diastolic heart failure: The worcester heart failure study," Coron Artery Dis., vol. 21, pp. 137-43, 2010.
B. K. Helfand, N. J. Maselli, D. M. Lessard, J. Yarzebski, J. M. Gore, D. D. McManus, J. S. Saczynski, and R. J. Goldberg, "Elevated serum glucose levels and survival after acute heart failure: A population-based perspective," Diab. Vasc. Dis. Res. Pii: 1479164114559024. [Epub Ahead of Print], 2014.
A. D. Shah, C. Langenberg, E. Rapsomaniki, S. Denaxas, M. Pujades-Rodriguez, C. P. Gale, J. Deanfield, L. Smeeth, A. Timmis, and H. Hemingway, "Type 2 diabetes and incidence of cardiovascular diseases: A cohort study in 1•9 million people," Lancet Diabetes Endocrinol. Pii, vol. S2213-8587, pp. 70219-0. Doi: 10.1016/S2213-8587(14)70219-0. [Epub Ahead of Print], 2014.
E. Ingelsson, J. Sundström, J. Arnlöv, B. Zethelius, and L. Lind, "Insulin resistance and risk of congestive heart failure," JAMA, vol. 294, pp. 334-341, 2005.
E. Ingelsson, J. Arnlöv, J. Sundström, B. Zethelius, B. Vessby, and L. Lind, "Novel metabolic risk factors for heart failure," J. Am. Coll. Cardiol., vol. 46, pp. 2054-2060, 2005.
H. Tsutsui, S. Kinugawa, and S. Matsushima, "Oxidative stress and heart failure," Am. J. Physiol. Heart Circ. Physiol., vol. 31, pp. H2181-90, 2011.
T. Oka, H. Akazawa, A. T. Naito, and I. Komuro, "Angiogenesis and cardiac hypertrophy: Maintenance of cardiac function and causative roles in heart failure," Circ. Res., vol. 114, pp. 565-571, 2014.
I. Shimizu, Y. Yoshida, T. Katsuno, and T. Minamino, "Adipose tissue inflammation in diabetes and heart failure," Microbes. Infect., vol. 15, pp. 11-17, 2013.
H. Tuunanen, E. Engblom, A. Naum, M. Scheinin, K. Någren, J. Airaksinen, P. Nuutila, P. Iozzo, H. Ukkonen, and J. Knuuti, "Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: Evidence of relationship with insulin resistance and left ventricular dysfunction," J. Card Fail, vol. 12, pp. 644-652, 2006.
I. Shimizu, Y. Yoshida, T. Katsuno, K. Tateno, S. Okada, J. Moriya, M. Yokoyama, A. Nojima, T. Ito, R. Zechner, I. Komuro, Y. Kobayashi, and T. Minamino, "p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure," Cell Metab., vol. 15, pp. 51-64, 2012.
J. Arnlöv, L. Lind, B. Zethelius, B. Andre?n, C. N. Hales, B. Vessby, and H. Lithell, "Several factors associated with the insulin resistance syndrome are predictors of left ventricular systolic dysfunction in a male population after 20 years of follow-up," Am. Heart J., vol. 142, pp. 720–724, 2001.
A. E. Berezin, A. A. Kremzer, T. A. Samura, and Y. V. Martovitskaya, "Circulating endothelial-derived apoptotic microparticles in the patients with ischemic symptomatic chronic heart failure: Relevance of pro-inflammatory activation and outcomes," Int. Cardiovasc Res. J., vol. 8, pp. 116-23, 2014.
A. E. Berezin, A. A. Kremzer, T. A. Samura, Y. V. Martovitskaya, Y. V. Malinovskiy, S. V. Oleshko, and T. A. Berezina, "Predictive value of apoptotic microparticles to mononuclear progenitor cells ratio in advanced chronic heart failure patients," J. Cardiol. Pii, vol. S0914-5087, pp. 00200-00207. doi: 10.1016/j.jjcc.2014.06.014. [Epub Ahead of Print], 2014.
A. D. Shah and M. C. Kontos, "Microparticles and left ventricular assist device complications: A causal association?," J. Heart Lung Transplant, vol. 33, pp. 468-469, 2014.
T. Nozaki, S. Sugiyama, K. Sugamura, K. Ohba, Y. Matsuzawa, M. Konishi, J. Matsubara, E. Akiyama, H. Sumida, K. Matsui, H. Jinnouchi, and H. Ogawa, "Prognostic value of endothelial microparticles in patients with heart failure," Eur. J. Heart Fail, vol. 12, pp. 1223-1228, 2010.
N. S. Barteneva, E. Fasler-Kan, M. Bernimoulin, J. N. Stern, E. D. Ponomarev, L. Duckett, and I. A. Vorobjev, "Circulating microparticles: Square the circle," BMC. Cell Biol., vol. 14, p. 23, 2013.
C. Guay and R. Regazzi, "Role of islet microRNAs in diabetes: Which model for which question?," Diabetologia, [Epub Ahead of Print], 2014.
Z. H. Wu, C. L. Ji, H. Li, G. X. Qiu, C. J. Gao, and X. S. Weng, "Membrane microparticles and diseases," Eur. Rev. Med. Pharmacol Sci., vol. 17, pp. 2420-2427, 2013.
C. Tetta, S. Bruno, V. Fonsato, M. C. Deregibus, and G. Camussi, "The role of microvesicles in tissue repair," Organogenesis, vol. 7, pp. 105-15, 2011.
M. C. Martinez and R. Andriantsitohaina, "Microparticles in angiogenesis: Therapeutic potential," Circ. Res., vol. 109, pp. 110–119, 2011.
P. E. Rautou, A. C. Vion, N. Amabile, G. Chironi, A. Simon, A. Tedgui, and C. M. Boulanger, "Microparticles, vascular function, and atherothrombosis," Circ. Res., vol. 109, pp. 593-606, 2011.
N. Kurtzman, L. Zhang, B. French, R. Jonas, A. Bantly, W. T. Rogers, J. S. Moore, M. R. Rickels, and E. R. Mohler, "Personalized cytomic assessment of vascular health: Evaluation of the vascular health profile in diabetes mellitus," Cytometry B. Clin. Cytom., vol. 84, pp. 255-266, 2013.
M. J. Lim and C. J. White, "Coronary angiography is the gold standard for patients with significant left ventricular dysfunction," Prog. Cardiovasc Dis., vol. 55, pp. 504-508, 2013.
R. M. Lang, L. P. Badano, V. Mor-Avi, J. Afilalo, A. Armstrong, L. Ernande, F. A. Flachskampf, E. Foster, S. A. Goldstein, T. Kuznetsova, P. Lancellotti, D. Muraru, M. H. Picard, E. R. Rietzschel, L. Rudski, K. T. Spencer, W. Tsang, and J. U. Voigt, "Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the merican society of echocardiography and the European association of cardiovascular imaging," J. Am. Soc. Echocardiogr., vol. 28, pp. 1-39, 2015.
D. Pellerin, R. Sharma, P. Elliott, and C. Veyrat, "Tissue doppler, strain, and strain rate echocardiography for the assessment of left and right systolic ventricular function," Heart, vol. 89, pp. iii9-17, 2003.
D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner, "Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man," Diabetologia, vol. 28, pp. 412–419, 1985.
A. S. Levey, L. A. Stevens, C. H. Schmid, Y. L. Zhang, A. F. Castro, H. I. Feldman, J. W. Kusek, P. Eggers, F. Van Lente, T. Greene, and J. Coresh, "For the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate," Ann. Intern. Med., vol. 150, pp. 604-612, 2009.
W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge," Clin. Chem., vol. 18, pp. 499-502, 1972.
A. F. Orozco and D. E. Lewis, "Flow cytometric analysis of circulating microparticles in plasma," Cytometry B. Clin. Cytom., vol. 77, pp. 502-514, 2010.
R. Lacroix, C. Judicone, M. Mooberry, M. Boucekine, N. S. Key, and F. Dignat-George, "The ISTH SSC workshop. Standardization of pre-analytical variables in plasma microparticle determination: Results of the international society on thrombosis and haemostasis SSC collaborative workshop," J. Thromb Haemost. Doi: 10.1111/jth.12207 [Epub Ahead of Print], 2013.
J. W. Tung, D. R. Parks, W. A. Moore, and L. A. Herzenberg, "New approaches to fluorescence compensation and visualization of FACS data," Clin. Immunol, vol. 110, pp. 277-283, 2004.
D. K. McGuire and M. O. Gore, "Insulin resistance and risk for incident heart failure," JACC Heart Fail, vol. 1, pp. 537-539, 2013.
W. Kosmala, C. L. Jellis, and T. H. Marwick, "Exercise limitation associated with asymptomatic left ventricular impairment: Analogy with stage B heart failure," J. Am. Coll. Cardiol. Pii, vol. S0735-1097, pp. 06991-06995. Doi: 10.1016/j.jacc.2014.10.044. [Epub Ahead of Print].
N. Giuseppina, P. Marinella, V. Claudia, S. Pietro, F. Marianna, D. M. Riccardo, G. F. Paolo, V. Giustina, and N. Salvatore, "Early subclinical ventricular dysfunction in patients with insulin resistance," J. Cardiovasc. Med. (Hagerstown), vol. 15, pp. 110-114, 2014.
O. Vardeny, D. K. Gupta, B. Claggett, S. Burke, A. Shah, L. Loehr, L. Rasmussen-Torvik, E. Selvin, P. P. Chang, D. Aguilar, and S. D. Solomon, "“Insulin resistance and incident heart failure: The ARIC study (Atherosclerosis Risk in Communities)," JACC Heart Fail, vol. 1, pp. 531-536, 2013.
G. Gouya, P. Voithofer, S. Neuhold, A. Storka, G. Vila, R. Pacher, M. Wolzt, and M. Hülsmann, "Association of nutritional risk index with metabolic biomarkers, appetite-regulatory hormones and inflammatory biomarkers and outcome in patients with chronic heart failure," Int. J. Clin. Pract., vol. 68, pp. 1293-300, 2014.
M. Doehner, Frenneaux, and S. D. Anker, "Metabolic impairment in heart failure: The myocardial and systemic perspective," J. Am. Coll. Cardiol., vol. 64, pp. 1388-1400, 2014.
K. Carvajal, J. Balderas-Villalobos, M. D. Bello-Sanchez, B. Phillips-Farfán, T. Molina-Muñoz, H. Aldana-Quintero, and N. L. Gómez-Viquez, "Ca2+ mishandling and cardiac dysfunction in obesity and insulin resistance: Role of oxidative stress," Cell Calcium., vol. 56, pp. 408-415, 2014.