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Cancers Review

June 2014, Volume 1, 1, pp 16-32

Prognostic Factors in Patients with Squamous Cell Carcinoma of the Oral Tongue Treated With Adjuvant Therapy Following Surgery

Valentina Krstevska

,

Snezhana Smichkoska

,

Beti Zafirova-Ivanovska

Valentina Krstevska 1
Snezhana Smichkoska 2
Beti Zafirova-Ivanovska 3

  1. Assistant Professor, Head of Department of Head and Neck Cancer, University Clinic of Radiotherapy and Oncology, Skopje, Republic of Macedonia 1

  2. Full Professor, Head of Department of Breast Cancer, University Clinic of Radiotherapy and Oncology, Skopje, Republic of Macedonia 2

  3. Full Professor, Director of the Institute of Epidemiology, Statistics and Informatics, Faculty of Medicine, Skopje, Republic of Macedonia 3

Pages: 16-32

DOI: 10.18488/journal.95/2014.1.1/95.1.16.32

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Abstract:

Background. There is limited data on adjuvant treatment following surgery in patients with squamous cell carcinoma of the oral tongue. 
Aims. This retrospective study investigates prognostic value of different factors for local relapse-free survival (LRFS), regional relapse-free survival (RRFS), disease-free survival (DFS), and overall survival (OS) in patients with oral tongue cancer treated with adjuvant therapy following surgery. 
Materials and methods. Forty six patients with surgically treated oral tongue cancer were enrolled in the analysis. Adjuvant therapy consisted of postoperative radiotherapy (PO-RT) or postoperative concurrent chemoradiotherapy (PO-CCRT). All patients received three dimensional conformal radiotherapy. Weekly cisplatin was given as concurrent chemotherapy. Identification of prognostic factors for survival was done with univariate analysis. Multivariate analysis was used for factors confirmed as significant on univariate analysis. 
Results. Independent prognostic factors negatively influencing LRFS, DFS, and OS were ECOG performance status (p = 0.002, p = 0.013 and p = 0.022, respectively), overall stage (p = 0.011, p = 0.010 and p = 0.009, respectively), and pathologic nodal classification (p = 0.016, p = 0.011 and p = 0.015, respectively). Surgical margin status was an independent prognostic factor for RRFS, DFS, and OS (p = 0.032, p = 0.027 and p = 0.028, respectively). The type of adjuvant treatment used was independently prognostic for lower rates of LRFS and DFS (p = 0.029 and p = 0.010, respectively).
Conclusions. Positive postoperative nodal status and close or positive resection margins had the most prominent negative prognostic influence on patients’ survival.  

Contribution/ Originality
This study is one of very few studies which have investigated potential prognostic factors that might influence treatment outcome exclusively in patients with squamous cell carcinoma originating from the oral tongue whose adjuvant therapy following surgery consisted of postoperative radiotherapy or postoperative concurrent chemoradiotherapy. 

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Reference:

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