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Prevalence of Prehypertension and Assessment of Renal Function among the Prehypertensive Students of the College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria

Okonkwo A.C

,

Ogbodo E.C

,

Okwara J.E

,

Ezeugwunne I.P

,

Analike R.A

,

Onah C.E

,

Amah U.K

,

Oha P.C

,

Obiorah M.O

,

Ugwu M.C

,

Meludu S.C

Okonkwo A.C 1 Ugwu M.C 1 

Meludu S.C 3 Ogbodo E.C 1 ,
;

Okwara J.E 5 Ezeugwunne I.P 3 Analike R.A 5 Onah C.E 8
Amah U.K 5 Oha P.C 10
Obiorah M.O 1 

  1. Department of Chemical Pathology, Nnamdi Azikiwe University, Nnewi Campus, Nigeria 1

  2. Department of Chemical Pathology, Nnamdi Azikiwe University, Nnewi Campus; Department of Human Biochemistry, Nnamdi Azikiwe University, Nnewi Campus, Nigeria 3

  3. Department of Chemical Pathology, Nnamdi Azikiwe University, Nnewi Campus; Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria 5

  4. Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria 8

  5. Department of Histopathology, Nnamdi Azikiwe University, Nnewi Campus, Nigeria 10

Pages: 73-87

DOI: 10.18488/journal.9.2017.45.73.87

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Article History:

Received: 26 May, 2017
Revised: 27 July, 2017
Accepted: 03 August, 2017
Published: 14 August, 2017


Abstract:

This study was carried out to determine the prevalence of pre-hypertension and assess the renal function in pre-hypertensive students in College of Health Sciences, Okofia, Nnewi. A total of 210 (99 males and 111 females) apparently healthy respondents aged 18-28, were recruited for the initial screening. Their blood pressure readings and body mass index (BMI) were obtained, whereas 5mls of blood sample was collected from 18 prehypertensive and 19 normotensive subjects. 5mls of blood was collect from eligible subjects and dispensed in plain containers for estimation of biochemical parameters. Serum creatinine, urea, Na+, K+, and Cl- were analyzed using standard methods. Result showed a prevalence of 11.4% with a higher percentage in males (12.12%) than in female (10.81%). BMI was significantly higher  in pre-hypertensive than in normotensive (26.31±4.76 Vs 21.60±2.44;p> 0.05). Systolic (SBP) and diastolic (DBP)(126.67±5.76 Vs 107.68±9.90; 79.56±6.57 Vs 69.52±7.39;p> 0.05) respectively were significantly higher in prehypertensives than in normotensives. Interestingly, there was no significant difference in the value of renal function markers of the prehypertensives when compared  to normotensives  (p>0.05). However, there was a positive correlation between SBP and serum urea level(r = 0.628; P =0.009). Therefore, the prevalence of prehypertension in this population was low with reference to studies in other populations. Importantly, this preliminary study did show that the renal functions are not compromised.

Contribution/ Originality
This study documents the Prevalence of Prehypertension and Assessment of Renal Function among the Prehypertensive Students of the College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria, a study which is original to the authors as outlined above.

Keywords:

Hypertension, Prehypertension, Creatinine, Urea ,Sodium ,Potassium, Chloride, Systolic blood pressure, Diastolic blood pressure.

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Statistics:

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Funding:

This study received no specific financial support.

Competing Interests:

The authors declare that they have no competing interests.

Acknowledgement:

I am highly grateful to God Almighty who has been my constant source of inspiration and strength and made it possible for this work to be success. In him I live, move and have my being and his grace is really sufficient for me. I wonder what the journey would have been like without his abiding love. Appreciation and immense gratitude to my supervisors; Prof. Meludu S.C. for his relentlessness and tireless efforts in overseeing this research study from start to completion. He was phenomenal and inspiring till the completion of this study, providing expertise guidance, immeasurable assistance and directives as well as psychological support and also by being available whenever his presence was required in order to make this work a success. My heartfelt thanks also go to Dr. Okwara John for his guidance and corrections in the course of this research work. Special thanks and recognitions to my parents Mr. and Mrs. Okonkwo for their inestimable encouragement, financial, psychological, moral and spiritual support. Both were fundamental to the completion of this work, being there for me when I needed them most. I must not fail to also acknowledge my Head of Department, Dr. Ibeh Nancy and Deaconess (Mrs.) Nora Mbadugha (Technical Head, Chemical Pathology Department, NAUTH, Nnewi) for their support during the course of this project work.

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