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Hypersensitivity to Natural Rubber Latex Gloves among Albanian Dental Students: The Role of Exposure Duration

Alketa Bakiri


Dhimiter Kraja


Skender Skenderaj


Doris Mingomataj


Elizana Petrela


Cerciz j Mingomata


Ariol Rama


Ervin C. Mingomataj

Alketa Bakiri 1
Dhimiter Kraja 2
Skender Skenderaj 3

Doris Mingomataj 4 Elizana Petrela 5
Cerciz j Mingomata 4 Ariol Rama 7
Ervin C. Mingomataj 8

  1. Logos University, Faculty of Applied Sciences, Department of Advanced Techniques in Medical Laboratory, Tirana, Albania; Albanian University, Faculty of Medical Sciences, Department of Stomatology, Tirana, Albania; Hygeia Hospital Tirana, Department 1

  2. Medicine University of Tirana, Faculty of General Medicine, Department of Infective and Dermato-Venerologic Diseases, Tirana, Albania 2

  3. Medicine University of Tirana, Faculty of General Medicine, Department of Environmental and Work Medicine, Tirana, Albania 3

  4. Albanian University, Faculty of Medical Sciences, Department of Stomatology, Tirana, Albania 4

  5. Medicine University of Tirana, Faculty of General Medicine, Department of Statistics and Epidemiology, Tirana, Albania 5

  6. Logos University, Faculty of Applied Sciences, Department of Advances Technics in Medical Laboratory, Tirana, Albania 7

  7. Medicine University of Tirana, Faculty of Technical-Medical Sciences, Department of Paraclinical Disciplines, Tirana, Albania; “Mother Theresa” School of Medicine, Department of Allergology and Clinical Immunology, Tirana, Albania 8

Pages: 45-49

DOI: 10.18488/journal.9.2017.43.45.49

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Article History:

Received: 15 February, 2017
Revised: 17 March, 2017
Accepted: 04 April, 2017
Published: 20 April, 2017


Latex allergy is a common occupational disease among healthcare workers who use latex gloves. The aim of the present study was to determine the prevalence of allergy to latex gloves among dental students and the role of exposure duration in latex allergy. In this prospective study, a total of 240 students completed a self-administered questionnaire aiming at providing information about glove, working habits, signs and symptoms related to glove use, precautions taken to minimize it, etc. The challenge and patch tests were performed through latex gloves, and skin prick test with commercial extracts. The questionnaire items and diagnostic tests revealed that one-fourth of subjects were suspicious for latex gloves hypersensitivity. Their mean value for skin reactions like contact urticaria, irritant or allergic dermatitis was between 10% and 14%, while for non-cutaneous symptoms the mean value was under 5%. The average latex exposure (in hours) is estimated to be about 214±71 (SE), with a maximum of 11500 hours. The correlation between studied variables and the time exposure to latex gloves revealed weak to moderate relations with respect to reported latex allergy, eczematous reactions, hand erythema after glove wearing, irritant reactions during wash/washout procedures, concentration oscillations during usage of latex gloves, or dyspnea attack during latex exposure. Due to the relationship between allergic reactions to latex gloves and some medical histories during school practice, it seems to be necessary to undergo pre-matriculation evaluation and periodic health surveillance of dental students.

Contribution/ Originality
AB designed the questionnaire, assisted students to complete them, conducted diagnostic tests and collected the data; DK and SS coordinated and helped with the study design and conduction; DM assisted on students’ enrollment in the study and helped with the study  design from the stomatological perspective; EP assisted on statistical analysis of the data; ÇM coordinated the students’ enrollment in the study; AR assisted on manuscript copyediting, EÇM drafted the manuscript.


Latex glove allergy, Questionnaire, Diagnostic tests, Dental students, Latex exposure duration, Allergy symptoms.



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This study received no specific financial support.

Competing Interests:

The authors declare that they have no competing interests.


All authors contributed equally to the conception and design of the study.

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