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Correlation between Her2/Neu and Histopatholoical Finding among Sudanese Female Breast Cancer Patients

Riyadh Hamed, Ahmed Abdelbadie, Ihsan Osman, El khazin Eltayeb, Husam Eldein Omer

Riyadh Hamed 1 ,

Ahmed Abdelbadie 2
Ihsan Osman 3
El khazin Eltayeb 1 Husam Eldein Omer 5

  1. Buraydah, Private College, KSA 1

  2. Alribat National University, Sudan 2

  3. Alzaiem Alazhari University, Sudan 3

  4. Jazan University, KSA 5

Pages: 62-69

DOI: 10.18488/journal.9/2015.2.4/9.4.62.69

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Abstract:

 Background: This study is one of very few studies which have investigated HER-2/neu expression and its correlation with histopathological finding. A total of 328 breast cancer tissue samples had been analyzed using immunohistochemical techniques. Objective: To compare the expression of tumor markers (HER-2/neu) with other prognostic parameters for mammary carcinomas. Results: Stage I- III B breast cancer HER-2/neu negative are (62%), whereas positive are (22%). Stage IV breast cancer HER-/neu negative are (4%), whereas positive are (3%).  Recurrent breast cancer HER-2/neu negative are (3%) while positive are (5%).Stage I breast cancer HER-2/neu negative are (10%), whereas positive are (1%).  Referring to stage II A, II B breast cancer HER-/neu negative are (59%), whereas positive are (16%). Stage III A, III B breast cancer HER-2/neu negative are (10%), while positive are (4%). HER-2/neu negative breast cancer Tumor size [le] 2 cm are (11%), while positive are (2%). HER-2/neu negative breast cancer Tumor size2-5 cm are (23%), whereas positive are (9%).HER-2/neu negative, Tumor size >5 cm are (26%), while positive are (29%). HER-2/neu negative breast cancer Nodal metastasis 0 are (5%), while positive are (2%). HER-2/neu negative Nodal metastasis1-9 are (16%), whereas positive are (19%). HER-2/neu negative breast cancer Nodal metastasis [ge] 10 are (28%), while positive are (30%). HER-2/neu negative histological subtype NIDC are (2%), whereas positive are (1%).  HER-2/neu negative histological subtype IDC are (67%), while positive are (25%).  HER-2/neu negative histological subtype ILC are (1%), whereas positive are (1%).  Lastly, HER-2/neu negative with others histological subtype are (3%), whereas positive are (0%). HER-2/neu negative histological grade I are (6%), whereas positive are (2%). HER-2/neu negative histological grade II are (21%), while positive are (7%).  Lastly, HER-2/neu negative histological grade II are (40%), whereas positive are (24%). HER-2/neu negative lympho-vascular invasion- are (71%), positive are (29%). HER-2/neu negative with lympho positive or vascular positive are (80%), While among positive are (16%). Conclusion: In this study population, the HER-2/neu expression its relation with histopathological finding determined.
Contribution/ Originality
This study contributes in the existing literature in Radiation Isotopes Centre Khartoum (RICK) among Sudanese female breast cancer patients. This study uses new estimation methodology of immunohistochemical techniques to understand HER-2/neu expression and its correlation with histopathological finding.

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Reference:

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