International Journal of Chemistry and Materials Research

Published by: Conscientia Beam
Online ISSN: 2311-763X
Print ISSN: 2312-0991
Quick Submission    Login/Submit/Track

Recent Articles

Synthesis and Cytotoxicity of Thiophene, Thieno[2,3-C]Pyrazole, Thieno[2,3-D]Pyrimidine and Pyridine Derivatives Derived from 2-Acetylfuran

Pages: 1-14
Find References

Finding References


Synthesis and Cytotoxicity of Thiophene, Thieno[2,3-C]Pyrazole, Thieno[2,3-D]Pyrimidine and Pyridine Derivatives Derived from 2-Acetylfuran

Search :
Google Scholor
Search :
Microsoft Academic Search
Cite

DOI: 10.18488/journal.64.2017.51.1.14

Abeer A. Mohamed , Amr S. Abouzied , Faten I. Hamed

Export to    BibTeX   |   EndNote   |   RIS


Abeer A. Mohamed , Amr S. Abouzied , Faten I. Hamed (2017). Synthesis and Cytotoxicity of Thiophene, Thieno[2,3-C]Pyrazole, Thieno[2,3-D]Pyrimidine and Pyridine Derivatives Derived from 2-Acetylfuran. International Journal of Chemistry and Materials Research, 5(1): 1-14. DOI: 10.18488/journal.64.2017.51.1.14
This work deals with the synthesis and cytotoxicity of some heterocyclic compounds starting from 2-acetylfuran. The title compound was used for the synthesis of thiophene derivative 3 through its reaction with elemental sulfur and ethyl cyanoacetate. Compound 3 was used for the synthesis of thiophene, thieno[2,3-c]pyrazole, thieno[2,3-d]pyrimidine and pyridine derivatives through its reaction with different reagents. The newly synthesized compounds were screened through three cancer cell lines.  Compound 13b showed the highest potency among the synthesized compounds.

Contribution/ Originality
This study contributes in the existing literature that thiophene derivatives can be produced from simple commercially available starting materials. The reactions of the produced thiophene derivative with different reagents gave both pyrazole and pyridine derivatives. The cytotoxicity of the produced products gave that some compounds with high potency.