The present study was conducted to evaluate the effect of Giardia on the
biochemical serum constituents of experimentally infected lambs, in
addition to studying the observed alterations accompanying Giardia
infection in the intestinal mucosa using scanning electron microscopy.
Twenty lambs were allotted into two equal groups, Group A ( non
infected) was kept as control negative and Group B (infected) was orally
inoculated by 104 Giardia cysts. The biochemical changes were assessed
in both groups on 7th. 14th, 21th and 30th days post inoculation (dpi).
The study disclosed that Giardia induced a significant drop in the
levels of serum electrolytes (chloride,sodium, potassium and calcium),
blood glucose, different enzymes (lipase, amylase and alkaline
phosphatase). Furthermore, the levels of urea, liver enzymes (alanine
aminotransferase and aspartate aminotransferase), inflammatory marker
(C-reactive protein) and oxidative stress marker (malondialdehyde) were
elevated, but nitric oxide was declined by 30th dpi. The scanning
electron microscopy of the intestinal mucosa of the infected lambs
revealed a notable alteration which was fully explained. All the
presented results interpret the pathophysiological effect of Giardia
which adversely affects the health status of lambs.
Giardia, Biochemical parameters, Oxidative stress, Electron microscopy.
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This study received no specific financial support.
The authors declare that they have no competing interests.
All authors contributed equally to the conception and design of the study.