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Mona Mlika , Wided Ajouli , Adel Marghli , Faouzi Mezni (2015). About the Pathogenesis of Myasthenia Gravis Associated With Thymic Enlargement. International Journal of Medical and Health Sciences Research, 2(7): 136-140. DOI: 10.18488/journal.9/2015.2.7/126.96.36.199
Introduction: A causal relationship between the thymus gland and myasthenia gravis (MG) has been assumed for decades. However, this relationship is still a matter of conjecture and speculations and awaits definitive proof. Recently, myoid cells have been considered as effectors in the pathogenesis of MG as well as thymic enlargement (thymolipoma, true thymic hyperplasia). Material and methods: we report a retrospective study about 6 cases of thymic enlargement with 4 cases of true thymic hyperplasia (TTH) and 2 cases of thymolipoma (TL). Aim: Our objective is to discuss the role of myoid cells in the pathogenesis of MG associated with thymic enlargement. Results: The majority of our patients were men with a sex ratio of 4/2. Only 2 patients had a past medical history consistent for MG. Myoid cells were found in all cases. Conclusion: Through our small study, the implication of myoid cells in the pathogenesis of the association MG-TL or TTH remains unproved.
This study contributes in the existing literature by enriching our knowledge about the pathogenesis of myasthenia gravis.
Malaysian Translation and Psychometric Evaluation for Parent and Child Questionnaires of Children Health Survey for Asthma
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Maryam SE Hussein , Waqas Akram , Nor Azizah Abu , Nahlah Elkudssiah binti Ismail (2015). Malaysian Translation and Psychometric Evaluation for Parent and Child Questionnaires of Children Health Survey for Asthma. International Journal of Medical and Health Sciences Research, 2(7): 122-135. DOI: 10.18488/journal.9/2015.2.7/188.8.131.52
This study aims to evaluate the reliability, and construct validity of the Malaysian versions of parent and child report of Children Health survey for Asthma. Questionnaires were translated to Bahasa Malaysia using previously established guidelines, a cross sectional study design and methodology was used to obtain the data, the study was recruited 180 respondents (7-16 years old) who have been diagnosed as asthmatic and their parents, SPSS version 20 was used to determine the reliability and construct validity. The results showed that all scores of cronbach’s alpha in the acceptable range ≥ 0.7. Both reliability and factor analyses reveal an acceptable reliability and a good construct validity of the scales.
This study documents the reliability and validity of the two version of CHSA. Both two instruments were translated to other language (Bahasa Malaysia) and evaluated their reliability and validity hence will help researchers from the same country to use these translated instruments in their studies. This current research dealt with asthmatic children and their parents to identify their point of views about the effect of asthma in their lives. In order of that, the findings from this research will contribute to knowledge and awareness among health practitioners and asthmatic patients and their family members that disease-related QoL also affects the successfulness of asthma management, not forgetting academia in filling the gaps in the literatures.