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Vandana KL , Saubhik Ghosh (2015). Radiographic Assessment of Alveolar Bone Crest Levels in 9-12 Year Old Children in Davangere, India. International Journal of Medical and Health Sciences Research, 2(4): 70-79. DOI: 10.18488/journal.9/2015.2.4/220.127.116.11
Background: Recent studies have indicated that aggressive periodontitis in the permanent dentition of adolescents often is preceded by bone loss in the primary and mixed dentition. Hence it is necessary to detect and treat these patients for preventing the transition of the disease from primary to permanent dentition. Aims and Objectives: The aim of this study was to radiographically determine the cemento-enamel junction (CEJ) to alveolar bone crest (ABC) distance in the interproximal areas of permanent molars and central incisors during the mixed dentition period. Materials and Methods: The study was a cross sectional study spanned over a period of one year. Panoramic radiographs were taken for 410 children residing in Davangere, Karnataka aged between 9-12 years. CEJ-ABC distance was measured at the mesial and distal surfaces of permanent first molars and permanent central incisors. Statistical analysis: Independent t-test was applied to compare CEJ–ABC distances measured in males and females, in the two age groups, the maxillary permanent central incisors and maxillary permanent first molars, the maxillary permanent first molars and mandibular permanent first molars. Results: The CEJ-ABC distance was less than 2mm in more than 95% of the sites. In some of the sites the distance when it was more than 2mm could be suggestive of normal physiology during mixed dentition period. Conclusion: The radiographic distance between CEJ-ABC if more than 2mm could be physiologic and hence requires to be deciphered by clinical evaluation.
Correlation between Her2/Neu and Histopatholoical Finding among Sudanese Female Breast Cancer Patients
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Background: This study is one of very few studies which have investigated HER-2/neu expression and its correlation with histopathological finding. A total of 328 breast cancer tissue samples had been analyzed using immunohistochemical techniques. Objective: To compare the expression of tumor markers (HER-2/neu) with other prognostic parameters for mammary carcinomas. Results: Stage I- III B breast cancer HER-2/neu negative are (62%), whereas positive are (22%). Stage IV breast cancer HER-/neu negative are (4%), whereas positive are (3%). Recurrent breast cancer HER-2/neu negative are (3%) while positive are (5%).Stage I breast cancer HER-2/neu negative are (10%), whereas positive are (1%). Referring to stage II A, II B breast cancer HER-/neu negative are (59%), whereas positive are (16%). Stage III A, III B breast cancer HER-2/neu negative are (10%), while positive are (4%). HER-2/neu negative breast cancer Tumor size [le] 2 cm are (11%), while positive are (2%). HER-2/neu negative breast cancer Tumor size2-5 cm are (23%), whereas positive are (9%).HER-2/neu negative, Tumor size >5 cm are (26%), while positive are (29%). HER-2/neu negative breast cancer Nodal metastasis 0 are (5%), while positive are (2%). HER-2/neu negative Nodal metastasis1-9 are (16%), whereas positive are (19%). HER-2/neu negative breast cancer Nodal metastasis [ge] 10 are (28%), while positive are (30%). HER-2/neu negative histological subtype NIDC are (2%), whereas positive are (1%). HER-2/neu negative histological subtype IDC are (67%), while positive are (25%). HER-2/neu negative histological subtype ILC are (1%), whereas positive are (1%). Lastly, HER-2/neu negative with others histological subtype are (3%), whereas positive are (0%). HER-2/neu negative histological grade I are (6%), whereas positive are (2%). HER-2/neu negative histological grade II are (21%), while positive are (7%). Lastly, HER-2/neu negative histological grade II are (40%), whereas positive are (24%). HER-2/neu negative lympho-vascular invasion- are (71%), positive are (29%). HER-2/neu negative with lympho positive or vascular positive are (80%), While among positive are (16%). Conclusion: In this study population, the HER-2/neu expression its relation with histopathological finding determined.
This study contributes in the existing literature in Radiation Isotopes Centre Khartoum (RICK) among Sudanese female breast cancer patients. This study uses new estimation methodology of immunohistochemical techniques to understand HER-2/neu expression and its correlation with histopathological finding.