F. Arnsten, "Stimulants: Therapeutic actions in ADHD," Neuropsychopharmacology, vol. 31, pp. 2376-2383, 2006.
T. E. Wilens, "Effects of methylphenidate on the catecholaminergic system in attention-deficit/hyperactivity disorder," J. Clin. Psychopharmacol, vol. 28, pp. S46-S53, 2008.
J. Swanson and R. D. Baler, "Volkow, N.D. Understanding the effects of stimulant medications on cognition in individuals with attention-deficit hyperactivity disorder: A decade of progress," Neuropsychopharmacology, vol. 36, pp. 207-226, 2011.
A. F. Arnsten, J. C. Steere, and R. D. Hunt, "The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function. Potential significance for attention-deficit hyperactivity disorder," Arch. Gen. Psychiatry, vol. 53, pp. 448-455, 1996.
S. R. Pliszka, J. T. McCracken, and J. W. Maas, "Catecholamines in attention-deficit hyperactivity disorder: Current perspectives," J. Am. Acad. Child Adolesc. Psychiatry, vol. 35, pp. 264-272, 1996.
A. J. Zametkin and J. L. Rapoport, "Neurobiology of attention deficit disorder with hyperactivity: Where have we come in 50 years?," J. Am. Acad. Child Adolesc. Psychiatry, vol. 26, pp. 676-686, 1987.
R. Kuczenski and D. S. Segal, "Exposure of adolescent rats to oral methylphenidate: Preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine," J. Neurosci., vol. 22, pp. 7264-7271, 2002.
P. Brun, M. F. Suaud-Chagny, F. Gonon, and M. Buda, "In vivo noradrenaline release evoked in the anteroventral thalamic nucleus by locus coeruleus activation: An electrochemical study," Neuroscience, vol. 52, pp. 961-972, 1993.
S. M. Florin-Lechner, J. P. Druhan, G. Aston-Jones, and R. J. Valentino, "Enhanced norepinephrine release in prefrontal cortex with burst stimulation of the locus coeruleus," Brain Res., vol. 742, pp. 89-97, 1996.
D. G. Amaral and H. M. Sinnamon, "The locus coeruleus: Neurobiology of a central noradrenergic nucleus," Prog. Neurobiol., vol. 9, pp. 147-196, 1977.
R. Y. Moore and F. E. Bloom, "Central catecholamine neuron systems: Anatomy and physiology of the norepinephrine and epinephrine systems," Annu. Rev. Neurosci., vol. 2, pp. 113-168, 1979.
W. Berridge and B. D. Waterhouse, "The locus coeruleus-noradrenergic system: Modulation of behavioral state and state-dependent cognitive processes," Brain Res. Brain Res. Rev., vol. 42, pp. 33-84, 2003.
G. Aston-Jones and F. E. Bloom, "Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle," J. Neurosci., vol. 1, pp. 876-886, 1981.
J. A. Hobson, R. W. McCarley, and P. W. Wyzinski, "Sleep cycle oscillation: Reciprocal discharge by two brainstem neuronal groups," Science, vol. 189, pp. 55-58, 1975.
L. Jacobs, "Single unit activity of locus coeruleus neurons in behaving animals," Prog. Neurobiol., vol. 27, pp. 183-194, 1986.
S. L. Foote, G. Aston-Jones, and F. E. Bloom, "Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal," Proc. Natl. Acad. Sci. U.S.A., vol. 77, pp. 3033-3037, 1980.
O. Gaytan, R. Nason, R. Alagugurusamy, A. Swann, and N. Dafny, "MK-801 blocks the development of sensitization to the locomotor effects of methylphenidate," Brain Res. Bull., vol. 51, pp. 485-492, 2000.
O. Gaytan, P. Yang, A. C. Swann, and N. Dafny, "Diurnal differences in sensitization to methylphenidate," Brain Res., vol. 864, pp. 24-39, 2000.
O. Gaytan, A. C. Swann, and N. Dafny, "Disruption of sensitization to methylphenidate by a single administration of MK-801," Life Sci., vol. 70, pp. 2271-2285, 2002.
P. B. Yang, B. Amini, A. C. Swann, and N. Dafny, "Strain differences in the behavioral responses of male rats to chronically administered methylphenidate," Brain Res., vol. 971, pp. 139-152, 2003.
P. B. Yang, A. C. Swann, and N. Dafny, "Dose-response characteristics of methylphenidate on locomotor behavior and on sensory evoked potentials recorded from the VTA, NAc, and PFC in freely behaving rats," Behav. Brain Funct., vol. 3, 2006.
P. B. Yang, A. C. Swann, and N. Dafny, "Chronic methylphenidate modulates locomotor activity and sensory evoked responses in the VTA and NAc of freely behaving rats," Neuropharmacology, vol. 51, pp. 546-556, 2006.
P. B. Yang, A. C. Swann, and N. Dafny, "Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains," Brain Res. Bull., vol. 71, pp. 301-310, 2006.
P. B. Yang, A. C. Swann, and N. Dafny, "Methylphenidate treated at the test cage--dose-dependent sensitization or tolerance depend on the behavioral assay used," Crit. Rev. Neurobiol., vol. 19, pp. 59-77, 2007.
P. B. Yang, A. C. Swann, and N. Dafny, "Chronic administration of methylphenidate produces neurophysiological and behavioral sensitization," Brain Res., vol. 1145, pp. 66-80, 2007.
P. B. Yang, A. C. Swann, and N. Dafny, "Psychostimulants given in adolescence modulate their effects in adulthood using the open field and the wheel-running assays," Brain Res. Bull., vol. 82, pp. 208-217, 2010.
B. Amini, P. B. Yang, A. C. Swann, and N. Dafny, "Differential locomotor responses in male rats from three strains to acute methylphenidate," Int. J. Neurosci., vol. 114, pp. 1063-1084, 2004.
B. Tang and N. Dafny, "Methylphenidate modulates the locus ceruleus neuronal activity in freely behaving rat," Eur. J. Pharmacol., vol. 695, pp. 48-56, 2012.
O. Gaytan, D. Ghelani, S. Martin, A. C. Swann, and N. Dafny, "Methylphenidate: Diurnal effects on locomotor and stereotypic behavior in the rat," Brain Res., vol. 777, pp. 1-12, 1997.
P. B. Yang, A. C. Swann, and N. Dafny, "Chronic pretreatment with methylphenidate induces cross-sensitization with amphetamine," Life Sci., vol. 73, pp. 2899-2911, 2003.
N. Dafny and P. B. Yang, "The role of age, genotype, sex, and route of acute and chronic administration of methylphenidate: A review of its locomotor effects," Brain Res. Bull., vol. 68, pp. 393-405, 2006.
M. E. Wolf, "The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants," Prog. Neurobiol., vol. 54, pp. 679-720, 1998.
O. Gaytan, S. Al-rahim, A. C. Swann, and N. Dafny, "Sensitization to locomotor effects of methylphenidate in the rat," Life Sci., vol. 61, pp. L101-L107, 1997.
R. C. Pierce and P. W. Kalivas, "A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants," Brain Res. Brain Res. Rev., vol. 25, pp. 192-216, 1997.
G. Paxinos and C. Watson, "The rat brain in stereotaxic coordinates," Physiol Behav. Ref Type: Serial (Book,Monograph), 1986.
N. Dafny, "The hypothalamus exhibits electrophysiologic evidence for morphine tolerance and dependence," Exp. Neurol., vol. 77, pp. 66-77, 1982.
N. Dafny, "Multiunit recording from medial basal hypothalamus following acute and chronic morphine treatment," Brain Res., vol. 190, pp. 584-592, 1980.
. Dafny and J. Terkel, "Hypothalamic neuronal activity associated with onset of pseudopregnancy in the rat," Neuroendocrinology, vol. 51, pp. 459-467, 1990.
N. Dafny, J. R. Lee, and P. M. Dougherty, "Immune response products alter CNS activity: Interferon modulates central opioid functions," J. Neurosci. Res., vol. 19, pp. 130-139, 1988.
M. Claussen and N. Dafny, "Acute and chronic methylphenidate modulates the neuronal activity of the caudate nucleus recorded from freely behaving rats," Brain Res. Bull., vol. 87, pp. 387-396, 2012.
S. L. Chong, C. M. Claussen, and N. Dafny, "Nucleus accumbens neuronal activity in freely behaving rats is modulated following acute and chronic methylphenidate administration," Brain Res. Bull., vol. 87, pp. 445-456, 2012.
R. L. Salek, C. M. Claussen, A. Perez, and N. Dafny, "Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats," Eur. J. Pharmacol., vol. 679, pp. 60-67, 2012.
B. Tang and N. Dafny, "Behavioral and dorsal raphe neuronal activity following acute and chronic methylphenidate in freely behaving rats," Brain Res. Bull., vol. 98, pp. 53-63, 2013.
P. Yang, A. C. Swann, and N. Dafny, "NMDA receptor antagonist disrupts acute and chronic effects of methylphenidate," Physiol Behav., vol. 71, pp. 133-145, 2000.
P. Yang, N. Singhal, G. Modi, A. C. Swann, and N. Dafny, "Effects of lithium chloride on induction and expression of methylphenidate sensitization," Eur. J. Pharmacol., vol. 426, pp. 65-72, 2001.
P. Yang, A. Beasley, K. Eckermann, A. Swann, and N. Dafny, "Valproate prevents the induction of sensitization to methylphenidate (Ritalin) in rats," Brain Res., vol. 887, pp. 276-284, 2000.
R. Kuczenski and D. S. Segal, "Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: Comparison with amphetamine," J. Neurochem., vol. 68, pp. 2032-2037, 1997.
J. Biederman and T. Spencer, "Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder," Biol. Psychiatry, vol. 46, pp. 1234-1242, 1999.
C. Drouin, M. Page, and B. Waterhouse, "Methylphenidate enhances noradrenergic transmission and suppresses mid- and long-latency sensory responses in the primary somatosensory cortex of awake rats," J. Neurophysiol., vol. 96, pp. 622-632, 2006.
P. Askenasy, K. H. Taber, P. B. Yang, and N. Dafny, "Methylphenidate (Ritalin): Behavioral studies in the rat," Int. J. Neurosci., vol. 117, pp. 757-794, 2007.
M. F. Wu, S. A. Gulyani, E. Yau, E. Mignot, B. Phan, and J. M. Siegel, "Locus coeruleus neurons: Cessation of activity during cataplexy," Neuroscience, vol. 91, pp. 1389-1399, 1999.
Aston-Jones, C. Chiang, and T. Alexinsky, "Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance," Prog. Brain Res., vol. 88, pp. 501-520, 1991.
Aston-Jones, M. T. Shipley, G. Chouvet, M. Ennis, B. E. Van, V. Pieribone, R. Shiekhattar, H. Akaoka, G. Drolet, and B. Astier, "Afferent regulation of locus coeruleus neurons: Anatomy, physiology and pharmacology," Prog. Brain Res., vol. 88, pp. 47-75, 1991.
E. J. Nestler, "Molecular mechanisms of drug addiction," Neuropharmacology, vol. 47, pp. 24-32, 2004.
Aston-Jones, J. Rajkowski, and J. Cohen, "Role of locus coeruleus in attention and behavioral flexibility," Biol. Psychiatry, vol. 46, pp. 1309-1320, 1999.
S. Bouret and S. J. Sara, "Network reset: A simplified overarching theory of locus coeruleus noradrenaline function," Trends Neurosci., vol. 28, pp. 574-582, 2005.
M. Weiss and P. E. Simson, "Neurochemical and electrophysiological events underlying stress-induced depression in an animal model," Adv. Exp. Med. Biol., vol. 245, pp. 425-440, 1988.
E. M. Nikulina, J. E. Marchand, R. M. Kream, and K. A. Miczek, "Behavioral sensitization to cocaine after a brief social stress is accompanied by changes in fos expression in the murine brainstem," Brain Res., vol. 810, pp. 200-210, 1998.
N. Carrey and M. Wilkinson, "A review of psychostimulant-induced neuroadaptation in developing animals," Neurosci. Bull., vol. 27, pp. 197-214, 2011.
Y. Kim, M. A. Teylan, M. Baron, A. Sands, A. C. Nairn, and P. Greengard, "Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens," Proc. Natl. Acad. Sci. U. S. A, vol. 106, pp. 2915-2920, 2009.
E. Fernandez-Espejo and N. Rodriguez-Espinosa, "Psychostimulant drugs and neuroplasticity," Pharmaceuticals, vol. 4, pp. 976-979, 2011.
Bin Tang , Nachum Dafny (2015). Locus Coeruleus Neuronal and Behavioral Activity Following Acute and Chronic Methylphenidate. Journal of Brain Sciences, 1(1): 24-42. DOI: 10.18488/journal.83/2015.1.1/184.108.40.206
Methylphenidate (MPD) is one of the choices to treat attention-deficit / hyperactivity disorder (ADHD), and its mechanism of action is not clear. Concomitant behavioral and locus coeruleus (LC) neuronal activity were recorded following acute and chronic (0.6, 2.5 and 10 mg/kg) MPD in freely moving rats. The experiment last for 10 days. (1) The behavioral recording showed that acute MPD increases in locomotor activity in a dose dependent manner. (2) The same dose of chronic MPD administration elicits in some animals behavioral sensitization and in others behavioral tolerance. (3) The majority of the LC unit responded to acute MPD exposure by increase their firing rate. (4) The baseline activity on experimental day 10 (ED 10) after six daily repetitive MPD exposure was modulated in most of the LC units. (5) More than 90% of the LC unit respond to chronic MPD exposure and the majority of them by decrease their firing rate compared to the initial MPD effect. (6) The neuronal response to acute and chronic MPD recorded from animals expressing behavioral sensitization was significant difference from the LC units recorded from animals that expressed behavioral tolerance. Results indicated that the LC neuronal activities may contribute to the expression of behavioral sensitization and tolerance induced by chronic MPD administration and suggested that it is essential to record the animal’s behavioral responses concomitantly with the LC neuronal activity events.
This paper is the first study which reported the acute and chronic dose response property of MPD on LC neuronal activity recorded concomitant with animal behavior. The study show neuronal activity recorded from behavioral sensitized animal response to MPD differently compare to those LC units recorded from behavioral tolerance animals.
Interventions for Reducing Coercion in Mental Health for Adults: A Systematic Review and the Impact of Updating
B. Molewijk, M. Verkerk, H. Milius, and G. Widdershoven, "Implementing moral case deliberation in a psychiatric hospital: Process and outcome," MedHealth Care Philos, vol. 11, pp. 43-56, 2008.
The Coordination Reform, "Proper treatment - at the right place and right time [Samhandlingsreformen: Rett Behandling - på rett sted - til rett tid] [Norwegian]," Norwegian Ministry of Health and Care Services, Oslo, Report No. 47 (2008-2009) to the Storting. Available: www.government.no, 2009.
A. B. Busch and M. F. Shore, "Seclusion and restraint: A review of recent literature," Harvard Review of Psychiatry, vol. 8, pp. 261-270, 2000.
J. Bak, V. Zoffmann, D. M. Sestoft, R. Almvik, and M. Brandt-Christensen, "Mechanical restraint in psychiatry: Preventive factors in theory and practice. A Danish-Norwegian association stud," Perspectives in Psychiatric Care, vol. 50, pp. 155-166, 2013.
K. T. Dahm, K. A. Leiknes, and T. L. Husum, "Interventions for reducing seclusion and restraint in mental health for adults [Effekt av tiltak for å redusere tvangsbruk i psykisk helsevern for voksne] [Norwegian]," Norwegian Knowledge Centre for the Health Services, Oslo, Report No. 09. Available: www.kunnskapssenteret.no, 2012.
R. Bremnes, T. Hatling, and J. H. Bjørngaard, "Use of coercion in mental health care in 2001, 2003, 2005 and 2007. [Bruk av tvangsmidler i psykisk helsevern i 2001, 2003, 2005 og 2007. SINTEF helse] [Norwegian]," Trondheim, Report A8231. Available www.sintef.no, 2008.
R. Bremnes, S. Lilleengen, P. B. Pedersen, H. S. Cederkvist, and M. S. Vestrheim, "Use of coercion in mental health care for adults 2012 [Bruk av tvang i psykisk helsevern for voksne 2012] [Norwegian]," Norwegian Directorate of Health [Helsedirektoratet], Oslo, Report. Available: www.helsedirektoratet.no, 2013.
L. Bowers, B. van der Werf, A. Vokkolainen, E. Muir-Cochrane, T. Allan, and J. Alexander, "International variation in containment measures for disturbed psychiatric inpatients: A comparative questionnaire survey," International Journal of Nursing Studies, vol. 44, pp. 357-364, 2007.
T. L. Husum, J. H. Bjorngaard, A. Finset, and T. Ruud, "A cross-sectional prospective study of seclusion, restraint and involuntary medication in acute psychiatric wards: Patient, staff and ward characteristics," BMC Health Services Research, vol. 10, p. 89, 2010.
T. W. Kallert, M. Glockner, and G. Onchev, "The EUNOMIA project on coercion in psychiatry: Study design and preliminary data," World Psychiatry, vol. 4, pp. 168-172, 2005.
S. R. Kisely, L. A. Campbell, and N. J. Preston, "Compulsory community and involuntary outpatient treatment for people with severe mental disorders," Cochrane Database of Systematic Reviews (Online), vol. 2, p. CD004408, 2011.
S. Muralidharan and M. Fenton, "Containment strategies for people with serious mental illness," Cochrane Database of Systematic Reviews, (Online), vol. 3, p. CD002084, 2006.
E. S. Sailas Eila and M. Fenton, "Seclusion and restraint for people with serious mental illnesses," Cochrane Database of Systematic Reviews, vol. 2, p. CD001163, 2000.
Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0, "Cochrane collaboration." [Updated March 2011 ]. Available www.cochrane-handbook.org, 2011.
G. Guyatt, A. Oxman, G. Vist, R. Kunz, and Y. Falck-Ytter, "An emergin consensus on rating quality of evidence and strength of recommmendations," BMJ, vol. 336, pp. 924-926, 2011.
C. Barbui and A. Cipriani, "What are evidence-based treatment recommendations?," Epidemiol Psychiatr Sci., vol. 20, pp. 29-31, 2011.
A. Putkonen, S. Kuivalainen, and O. Louheranta, "Cluster-randomized controlled trial of reducing seclusion and restraint in secured care of men with schizophrenia," Psychiatric Services (Washington, DC), vol. 64, pp. 850-855, 2013.
G. Thornicroft, S. Farrelly, and G. Szmukler, "Clinical outcomes of joint crisis Plans to reduce compulsory treatment for people with psychosis: A randomised controlled trial," The Lancet, vol. 381, pp. 1634-1641, 2013.
Georgieva, C. L. Mulder, and E. Noorthoorn, "Reducing seclusion through involuntary medication: A randomized clinical trial," Psychiatry Research, vol. 205, pp. 48-53, 2013.
G. Huf, E. Coutinho, and C. Adam, "Physical restraints versus seclusion room for management of people with acute aggression or agitation due to psychotic illness (TREC-SAVE): A randomized trial," Psychological Medicine, vol. 42, pp. 2265-2273, 2012.
M. Knutzen, S. Bjorkly, and G. Eidhammer, "Mechanical and pharmacological restraints in acute psychiatric wards-why and how are they used?," Psychiatry Research, vol. 209, pp. 91-97, 2012.
M. Knutzen, S. Bjorkly, and G. Eidhammer, "Mechanical and pharmacological restraints in acute psychiatric wards-why and how are they used?," Psychiatry Res., vol. 209, pp. 91-97, 2013.
A. B. P. Staring, M. Van Der Gaag, and G. T. Koopmans, "Treatment adherence therapy in people with psychotic disorders: Randomised controlled trial," British Journal of Psychiatry, vol. 197, pp. 448-455, 2010.
P. Tyrer, F. Gordon, and S. Nourmand, "Controlled comparison of two crisis resolution and home treatment teams," Psychiatrist, vol. 34, pp. 50-54, 2010.
Ohlenschlaeger, M. Nordentoft, and A. Thorup, "Effect of integrated treatment on the use of coercive measures in first-episode schizophrenia-spectrum disorder. A randomized clinical trial," International Journal of Law and Psychiatry, vol. 31, pp. 72-76, 2008.
G. Davidson and J. Campbell, "An examination of the use of coercion by assertive outreach and community mental health teams in Northern Ireland," British Journal of Social Work, vol. 37, pp. 537-555, 2007.
A. I. Wierdsma, H. D. Poodt, and C. L. Mulder, "Effects of community-care networks on psychiatric emergency contacts, hospitalisation and involuntary admission," Journal of Epidemiology and Community Health, vol. 61, pp. 613-618, 2007.
S. Johnson, F. Nolan, and J. Hoult, "Outcomes of crises before and after introduction of a crisis resolution team," The British Journal of Psychiatry: The Journal of Mental Science, vol. 187, pp. 68-75, 2005.
C. Henderson, C. Flood, M. Leese, G. Thornicroft, K. Sutherby, and G. Szmukler, "Effect of joint crisis plans on use of compulsory treatment in psychiatry: Single blind randomised controlled trial," BMJ (Clinical Research Ed), vol. 329, p. 136, 2004.
R. Van De Sande, H. L. I. Nijman, and E. O. Noorthoorn, "Aggression and seclusion on acute psychiatric wards: Effect of short-term risk assessment," British Journal of Psychiatry, vol. 190, pp. 473-478, 2011.
Ohlenschlaeger, A. Thorup, and L. Petersen, "Intensive treatment models and coercion," Nordic Journal of Psychiatry, vol. 61, pp. 369-378, 2007.
C. Abderhalden, I. Needham, T. Dassen, R. Halfens, H. J. Haug, and J. E. Fischer, "Structured risk assessment and violence in acute psychiatric wards: Randomised controlled trial," The British Journal of Psychiatry: The Journal of Mental Science, vol. 193, pp. 44-50, 2008.
S. Rosenman, A. Korten, and L. Newman, "Efficacy of continuing advocacy in involuntary treatment," Psychiatric Services, vol. 51, pp. 1029-1033, 2000.
D. A. Pollack, B. H. McFarland, J. M. Mahler, and A. E. Kovas, "Outcomes of patients in a low-intensity, short-duration involuntary outpatient commitment program," Psychiatric Services, vol. 56, pp. 863-866, 2005.
A. Papageorgiou, M. King, A. Janmohamed, O. Davidson, and J. Dawson, "Advance directives for patients compulsorily admitted to hospital with serious mental illness. Randomised controlled trial," The British Journal of Psychiatry: The Journal of Mental Science, vol. 181, pp. 513-519, 2002.
G. Eidhammar, F. Fluttert, M. Knutzen, and S. Bjørkly, "Early recognition method - ERM - pilotfase 2 - 2009-2013. Kompetansesenter for sikkerhet-, fengsels- og rettspsykiatri Helseregion Sør Øst," Oslo, Report No. 2013-012013.
F. A. Fluttert, M. B. Van, H. Nijman, S. Bjorkly, and M. Grypdonck, "Preventing aggressive incidents and seclusions in forensic care by means of the 'early recognition method," J Clin Nurs, vol. 19, pp. 1529-1537, 2010.
S. B. Goetz and A. Taylor-Trujillo, "A change in culture: Violence prevention in an acute behavioral health setting," J Am Psychiatr Nurses Assoc., vol. 18, pp. 96-103, 2012.
Hustoft, T. K. Larsen, B. Auestad, I. Joa, J. O. Johannessen, and T. Ruud, "Predictors of involuntary hospitalizations to acute psychiatry," International Journal of Law and Psychiatry, vol. 36, pp. 136-143, 2013.
Bowers, G. Brennan, C. Flood, M. Lipang, and P. Oladapo, "Preliminary outcomes of a trial to reduce conflict and containment on acute psychiatric wards: City nurses," Journal of Psychiatric and Mental Health Nursing, vol. 13, pp. 165-172, 2006.
E. Sailas and K. Wahlbeck, "Restraint and seclusion in psychiatric inpatient wards," Current Opinion in Psychiatry, vol. 18, pp. 555-559, 2005.
Kristin Thuve Dahm , Jan Odgaard-Jensen , Tonje Lossius Husum , Kari Ann Leiknes (2015). Interventions for Reducing Coercion in Mental Health for Adults: A Systematic Review and the Impact of Updating. Journal of Brain Sciences, 1(1): 1-23. DOI: 10.18488/journal.83/2015.1.1/220.127.116.11
Background: Reduction of use of coercive measures in Mental Health Care has been of increasing concern for patient organizations, governmental agents and health policy makers. Aim: To examine the effectiveness of psychosocial interventions intended to reduce coercion in mental health for adults. Methods: We conducted a systematic review in 2012 and update in 2013. Studies with control groups were included. Assessment of risk of bias and meta-analyses of randomized controlled studies was undertaken. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool for evaluating the overall quality of evidence was used and expressed in four categories: high, moderate, low and very low. Results: Fifteen studies met the inclusion criteria. For the intervention Joint crisis plan, a reduction in the number of patients admitted involuntarily could not be verified by meta-analyses (RR 0.71 (95% CI 0.38–1.33), P=0.28). Quality of evidence was assessed as low by GRADE and the results should be interpreted with caution. Risk assessment of aggressive behaviour in acute psychiatric wards and counselling towards staff in high security wards seemed to reduce seclusion and restraint, but for these interventions meta-analyses was not feasible. Conclusion: Joint crisis plans for reducing coercion is unclear. Risk assessment and counselling towards staff may reduce coercion.
Declaration of interest None
This paper highlights the importance of updating previous systematic literature reviews. Newer studies added on made meta-analyses feasible, modifying earlier conclusions.