Mohammad Sayyed Bakheet, Mohamed Ismail Seddik, M H Abdelzaher, Mohammad Mohammad Abolfotoh, Abdelaziz eldarwesh, Alomairi Mostafa M, Maher Abdelshakor
Mohammad Sayyed Bakheet 1
Mohamed Ismail Seddik 2 M H Abdelzaher 1Mohammad Mohammad Abolfotoh 1Abdelaziz eldarwesh 5 Alomairi Mostafa M 1Maher Abdelshakor 7
Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assuit, Egypt 1
Department of clinical pathology, Faculty of Medicine, Assuit University, Egypt 2
Department of obstetrics and gynecology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt 5
Department of physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt 7
TNF– α directly damages the vascular endothelial cells, reduces regional blood flow, causes occlusion of vessels and increases endothelial permeability. Endothelial cell injury after TNF– α mediated activation of immune system may result in secretion of vasoactive substances and increase in vascular permeability and intravascular coagulation. TNF-α may be involved in the pathogenesis of preeclampsia and may identify the patients who are at high risk of PE and can be a potential marker of the severity of the preeclamptic syndrome. Preeclamptic women had deranged lipid profile due to abnormal lipid metabolism; this alteration of lipid metabolism may play a key role in the development of symptoms of Pre-eclampsia. Furthermore, changes to lipid metabolism may contribute towards the endothelial lesions observed in pre-eclampsia.
Keywords:
Preeclampsia, TNF– Α, Lipid Per-Oxidation and nitric oxide.
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