Many studies have endeavored to quantify the potential of the structural system to delimit the seismic force level imposed by virtue of their ductility and energy absorption capacity. The response modification factor (R) is defined as the ratio of the absolute maximum linear elastic base shear to the absolute maximum nonlinear base shear of structure subjected to the same earthquake acceleration. The response modification factor (R) depends on over-strength (Rs),_ductility_(Rµ)- ,_and redundancy_(Rr). In the current study, the R factor is investigated for multistory reinforced concrete flat slab structures. A non-linear time-history analysis based on the _applied element method was carried out on ten stories RC flat slab structure with shear wall resisting system for lateral loads. A parametric study was conducted to investigate the effect of different parameters on the R factor such as earthquake acceleration magnitude, structural natural period, height of the building, reinforcement ratio, geometric configuration, and material strength properties. The results showed that the value of (R) depends not only on structure dynamic properties but also on its nonlinearity and on earthquake magnitude which is not only considered in the current world wide design codes.