TY - EJOU AU - T1 - Synthesis, Anti-Inflammatory, Analgesic, Molecular Modeling and Admet Studies of Novel Diclofenac Derivatives Containing Leucinyl Moiety T2 - International Journal of Chemistry and Materials Research PY - 2013 VL - 1 IS - 1 SN - 2311-763X AB - The present work aims to synthesize novel diclofenac derivatives containing L-leucine moiety. The synthesized compounds docked into the active site to discover validated inhibitors of cyclooxygenases (COX-1 and COX-2). The calculations in-silico were predicted that, the compound with lowest energy of docked poses was interacted with residues of active site, perhaps could be making them possible selective inhibitors against (COX-2) and physiologically  active. The binding score of compound compared with reference drug, and show extensive interactions with the targets, which may consider it a suitable selective inhibitor against   (COX-2). KW - DO -