@Article{pakinsight,
AUTHOR = {},
TITLE = {Synthesis, Physico-Chemical and Antimicrobial Properties of Some Metal (II) -Mixed Ligand Complexes of Tridentate Schiff Base Derives From Β-Lactam Antibiotic {(Cephalexin Mono Hydrate)-4-Chlorobenzophenone} and Saccharin},
JOURNAL = {International Journal of Chemical and Process Engineering Research},
VOLUME = {1},
YEAR = {2014},
NUMBER = {6},
PAGES = {109-120},
URL = {http://www.pakinsight.com/archive/65/06-2014/6},
ISSN = {2313-0776},
ABSTRACT = {A new Schiff base (4-chlorophenyl)(phenyl methanimine (6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate=HL=C29H24ClN3O4S) has been synthesized from β-lactam antibiotic (cephalexin mono hydrate (CephH)=(C16H19N3O5S.H2O) and 4- chlorobenzophenone. Metal  mixed ligand   complexes of the Schiff base were prepared from chloride salt of   Fe(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), in 50% (v/v) ethanol – water medium in  aqueous ethanol(1:1) and Saccharin(C7H5NO3S) containing   sodium hydroxide. Several physical tools in particular; IR, C:H:N , 1H NMR,13C NMR for ligand, melting  point,  molar conductance, magnetic moment. and determination of the percentage of  the metal  in  the  complexes  by  flame(AAS). The   ligand   and   their metal complexes were   screened for   their antimicrobial activity against   four bacteria (gram +ve) and (gram -ve) [Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus]. The proposed structure of the complexes using the program, Chem office 3D (2006) and the general formula have been given for the prepared mixed ligand complexes [M(Sac)3(L)].},
DOI = {10.18488/journal.65/2014.1.6/65.6.109.120}
}