@Article{pakinsight,
AUTHOR = {},
TITLE = {Synthesis, Anti-Inflammatory, Analgesic, Molecular Modeling and Admet Studies of Novel Diclofenac Derivatives Containing Leucinyl Moiety},
JOURNAL = {International Journal of Chemistry and Materials Research},
VOLUME = {1},
YEAR = {2013},
NUMBER = {1},
PAGES = {1-13},
URL = {http://www.pakinsight.com/archive/64/11-2013/1},
ISSN = {2311-763X},
ABSTRACT = {The present work aims to synthesize novel diclofenac derivatives containing L-leucine moiety. The synthesized compounds docked into the active site to discover validated inhibitors of cyclooxygenases (COX-1 and COX-2). The calculations in-silico were predicted that, the compound with lowest energy of docked poses was interacted with residues of active site, perhaps could be making them possible selective inhibitors against (COX-2) and physiologically  active. The binding score of compound compared with reference drug, and show extensive interactions with the targets, which may consider it a suitable selective inhibitor against   (COX-2).},
DOI = {}
}