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Asiatic acid (AA) is a pentacyclic triterpene in the leaf of the plant Centella asiatica (CA) is known to inhibit proliferation and induce apoptosis in several tumor cell lines. Plants are playing a significant role in human life as food, shelter and stability of the ecosystem. Most importantly to humans, it is currently estimated that 50% of all drugs in clinical use has been derived from natural products and at least 25% of all prescription drugs contain ingredients extracted from plants. In the present study, the antiproliferative activity of various concentrations (10, 20, 30, 40, 50, 60 µg/ml) of AA, a active principle of CA, on human Hep G2 liver cell lines (untreated and treated) was determined by the MTT assay based on the detection of mitochondrial dehydrogenase activity in living cells. The study reveals that the AA effectively inhibits the growth of cancer cells in concentration dependent manner and at a high of 85 % at the concentration of 50µg/ml.
A Review on the Use of Moxifloxacin in Multidrug Resistant Tuberculosis
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The first line anti-tuberculosis drugs have shown an increasing prevalence of resistance. The higher incidence of TB has led to stronger requirements of other therapies apart from the World Health Organisation recommended Directly Observed Therapy in Short course (DOTS). New drugs highly effective against Mycobacterium tuberculosis (MTB) could enhance the treatment of cases with resistance to first line drugs (isoniazid and rifampicin) and may curtail the extent of present regular regimes. Fluoroquinolones are reasonably effective against Mycobacterium tuberculosis (MTB). They have been used as alternative for some present first-line drugs such as Isoniazid, and have been efficient even in Multi Drug Resistant Tuberculosis. These efforts must be further enhanced to ensure ultimate success in discovering, developing, and delivering drastically improved therapies for tuberculosis patients.
The paper’s primary contribution is finding that Moxifloxacin may curtail the time duration and adverse events in the case of multi drug resistant tuberculosis.